In the United States, there are approximately 4 million births per year and childbirth is the leading indication for hospitalization. Correspondingly, the prevention of adverse obstetric outcomes, including preterm birth and maternal morbidity, is an important goal, and clinical trials and observational studies designed to improve obstetric outcomes are of the utmost importance. The Maternal-Fetal Medicine Units (MFMU) Network, by creating a multi-institutional research infrastructure, is an important mechanism to accomplish this goal effectively. The Northwestern Study Center, through its use of innovative recruitment techniques and study design approaches, has been a productive member of the MFMU Network since 2001, and is composed of two institutions that have worked together in the MFMU Network for over 10 years: Northwestern University and NorthShore University Health System. The two Maternal-Fetal Medicine Divisions of the institutions, in addition, have a long and continuing collaboration on multiple other clinical research studies and trials. In this proposal, we present the application of the Northwestern Study Center to renew its participation in the MFMU Network. Led by a team of experienced clinical researchers (William Grobman, MD, MBA; Alan Peaceman, MD; Mara Dinsmoor, MD, MPH; Gail Mallett, RN), the Northwestern Study Center will continue its significant contributions to the MFMU Network's goals though robust enrollment of socioeconomically diverse patients and the conception and development of novel studies.

Public Health Relevance

Obstetric admissions are the leading cause of hospitalization in the United States, and a significant portion of the obstetric population experiences morbidity that has the potential to adversely affect both women and children immediately as well as for years after birth. Northwestern University, as part of the MFMU Network, will substantively contribute to the large-scale clinical trials and observational studies that are needed to improve obstetric outcomes and thereby enhance public health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Clinical Research Cooperative Agreements - Single Project (UG1)
Project #
5UG1HD040512-18
Application #
9234570
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Miodovnik, Menachem
Project Start
2001-04-01
Project End
2021-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
18
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Randis, Tara M; Rice, Madeline Murguia; Myatt, Leslie et al. (2018) Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis. J Perinat Med 46:926-933
Clark, Erin A S; Weiner, Steven J; Rouse, Dwight J et al. (2018) Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth. Am J Perinatol 35:1012-1022
Pasko, Daniel N; McGee, Paula; Grobman, William A et al. (2018) Variation in the Nulliparous, Term, Singleton, Vertex Cesarean Delivery Rate. Obstet Gynecol 131:1039-1048
Tita, Alan T N; Jablonski, Kathleen A; Bailit, Jennifer L et al. (2018) Neonatal outcomes of elective early-term births after demonstrated fetal lung maturity. Am J Obstet Gynecol 219:296.e1-296.e8
Grobman, William A; Bailit, Jennifer; Sandoval, Grecio et al. (2018) The Association of Decision-to-Incision Time for Cesarean Delivery with Maternal and Neonatal Outcomes. Am J Perinatol 35:247-253
Saade, G R; Thom, E A; Grobman, W A et al. (2018) Cervical funneling or intra-amniotic debris and preterm birth in nulliparous women with midtrimester cervical length less than 30 mm. Ultrasound Obstet Gynecol 52:757-762
Chauhan, Suneet P; Weiner, Steven J; Saade, George R et al. (2018) Intrapartum Fetal Heart Rate Tracing Among Small-for-Gestational Age Compared With Appropriate-for-Gestational-Age Neonates. Obstet Gynecol 132:1019-1025
Kominiarek, Michelle A; Saade, George; Mele, Lisa et al. (2018) Association Between Gestational Weight Gain and Perinatal Outcomes. Obstet Gynecol 132:875-881
Grobman, William A; Bailit, Jennifer; Lai, Yinglei et al. (2018) Defining failed induction of labor. Am J Obstet Gynecol 218:122.e1-122.e8
Kominiarek, Michelle A; Smid, Marcela C; Mele, Lisa et al. (2018) Child Neurodevelopmental Outcomes by Prepregnancy Body Mass Index and Gestational Weight Gain. Obstet Gynecol 132:1386-1393

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