Obesity and the constellation of associated metabolic risk factors (atherogenic dyslipidemia, hyperglycemia, hypertension, hepatic steatosis, prothrombotic and proinflammatory states) contribute importantly to death and disability in the United States. The mechanisms responsible for obesity and the metabolic syndrome have resisted elucidation through conventional approaches. Experts in the field have proposed that progress towards understanding the gene/environment interactions causing obesity will require the implementation of a broad-based clinical and basic research program. To develop such a program, we have assembled a highly interactive and collaborative interdisciplinary team of experts at UT Southwestern called the Taskforce for Obesity Researchat Southwestern (TORS). TORS harnesses expertise from highly diverse disciplines, with a goal of defining the behavioral, metabolic, genetic and molecular mechanisms contributing to obesity and the metabolic syndrome. Our accomplishments during the past 2 years of P20 funding demonstrate that we have successfully integrated traditionally disparate disciplines of anatomy, biochemistry, chemistry, genetics, lipid metabolism, molecular biology, intermediary metabolism, neuroendocrinology, nutrition, pharmacology, physiology, and clinical epidemiology into a cohesive Interdisciplinary Research Consortium to study obesity and the metabolic syndrome. The strength of our faculty and the support of our administration provide TORS with the expertise, infrastructure, and ability to develop new approaches to the elucidation and prevention of obesity-associated diseases. Successful completion of the studies described in this grant will provide much needed insights into the key molecules and pathways that govern whole-body energy metabolism, which will be translated into the development of new approaches to prevent obesity and to treat the metabolic complications of this disorder.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1DE019584-05
Application #
8102063
Study Section
Special Emphasis Panel (ZRR1-SRC (99))
Program Officer
Riddle, Melissa
Project Start
2007-09-24
Project End
2013-06-30
Budget Start
2011-07-01
Budget End
2013-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$384,760
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
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