The purpose of this Interdisciplinary Research Consortium grant application is to focus on the fertility threat poised by cancer treatment and to serve as an authoritative voice for research, clinical practice and training that will happen at the -intersection of oncology, pediatrics, reproductive science and medicine, biomechanics, materials science, mathematics, social science bioethics, religion, policy research, reproductive health law, cognitive and learning science in a new discipline called ONCOFERTILITY. We have assembled outstanding scientists, clinicians and scholars to address the following questions: How do we optimally store and recovery gonadal tissue (R01A)? Can we promote primate-derived immature follicle growth and oocyte maturation in a three-dimensional environment (R01B and R01C)? What is the specific fertility threat of the life-preserving cancer drugs (R01C, KOI)? Can we cryopreserve and grow human ovarian follicles (R01A, R01C)? Can we predict how new cancer drugs will affect fertility (R01C)? What are the ethical and legal concerns surrounding the use of advanced reproductive technologies in cancer patients (R01D)? What is the cost/benefit analysis of fertility preservation (R01D)? How do families facing a child's cancer diagnosis decide whether or not to participate in the ovarian cryopreservation work (R01D)? What role do healthcare practitioners and religious counsel play in the decision (R01D)? How do women with cancer share their concerns regarding infertility with their physician and how does their decision impact their lives and relationships after cancer (R01D)? What are the key concerns and treatment decisions that are made at diagnosis and how does gender, race/ethnicity, socioeconomic and family status factor into the equation (R01D)? Supporting these studies are a biomaterial core (P30A) and a ovarian tissue collection core (P30B). Supporting the learning and training programs of this grant are a R25 and a T90/R90. Collectively, this grant serve as a framework into which this exceptionally exciting, challenging and multifaceted new discipline of oncofertility can be fostered and can, in the end, create new knowledge about the process of ovarian follicle development and provide the medical solution to fertility preservation for women with a fertility-altering cancer diagnosis. In so doing, oncofertility medical specialists, oncofertility scientists and oncofertility scholars will, for the first time, provide viable options to women with cancer and other fertility-threatening diseases, learn more about the nature and mechanisms of follicle development and better understand human relationships between health, disease and interventions that can protect the options for future fertility.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Linked Specialized Center Cooperative Agreement (UL1)
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Special Emphasis Panel (ZRR1-SRC (99))
Program Officer
Riddle, Melissa
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Northwestern University at Chicago
Obstetrics & Gynecology
Schools of Medicine
United States
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Laronda, Monica M; McKinnon, Kelly E; Ting, Alison Y et al. (2017) Good manufacturing practice requirements for the production of tissue vitrification and warming and recovery kits for clinical research. J Assist Reprod Genet 34:291-300
Lungeanu, Alina; Contractor, Noshir S (2015) The effects of diversity and network ties on innovations: The emergence of a new scientific field. Am Behav Sci 59:548-564
Woodruff, Teresa K (2015) Oncofertility: a grand collaboration between reproductive medicine and oncology. Reproduction 150:S1-10
Xu, Jing; McGee, Whitney K; Bishop, Cecily V et al. (2015) Exposure of female macaques to Western-style diet with or without chronic T in vivo alters secondary follicle function during encapsulated 3-dimensional culture. Endocrinology 156:1133-42
Laronda, Monica M; Jakus, Adam E; Whelan, Kelly A et al. (2015) Initiation of puberty in mice following decellularized ovary transplant. Biomaterials 50:20-9
Lawson, Angela K; Klock, Susan C; Pavone, Mary Ellen et al. (2015) Psychological Counseling of Female Fertility Preservation Patients. J Psychosoc Oncol 33:333-53
Kim, So-Youn; Ebbert, Katherine; Cordeiro, Marilia H et al. (2015) Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Endocrinology 156:1464-76
Lawson, Angela K; Klock, Susan C; Pavone, Mary Ellen et al. (2014) Prospective study of depression and anxiety in female fertility preservation and infertility patients. Fertil Steril 102:1377-84
Lungeanu, Alina; Huang, Yun; Contractor, Noshir S (2014) Understanding the assembly of interdisciplinary teams and its impact on performance. J Informetr 8:59-70
Laronda, Monica M; Duncan, Francesca E; Hornick, Jessica E et al. (2014) Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue. J Assist Reprod Genet 31:1013-28

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