This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This CTSA application from Washington University in St. Louis (WU) is built on a long institutional history of outstanding biomedical research, research training, and patient care. WU is the recipient of the 4 clinical research and training grants that form the basis of the CTSA (GCRC, currently in its 46th year of funding, and K12, K30, and T32 grants.) Another critical element is WU's new BioMed 21 strategic initiative in multidisciplinary, collaborative research in genome sciences, biological imaging, and clinical investigation. All these elements will be conjoined with other existing resources at WU to form a transformational new Institute of Clinical and Translational Sciences (ICTS). By implementing the 15 key Program Functions described in this application, the ICTS will conceptually and operationally reinvent and reinvigorate clinical and translational research and clinical research training at WU. An unprecedented level of partnership with other academic, healthcare, community and scientific institutions that complement our core expertise in laboratory and clinical research and research training is central to the transformation that will be led by the ICTS. Our partners include BJC HealthCare, an integrated academic and community health care delivery system;Saint Louis University School of Public Health, Graduate School and Doisy College of Health Sciences;University of Missouri St. Louis College of Nursing;Southern Illinois University Edwardsville School of Nursing;and St. Louis College of Pharmacy;key organizations promoting community health as well as biomedical and pharmaceutical companies in the St. Louis area. The coupling of these resources creates an outstanding environment to make basic laboratory discoveries that can then be translated into clinical research protocols and ultimately into advances in clinical practice and patient care through extensive community interactions and commercial partnerships."""""""" To ensure the success of the ICTS, WU has made substantial commitments of space and financial support. Barnes-Jewish and St. Louis Children's Hospitals, our academic hospital-partnersrand-BdC HealthCare, our affiliated health system, have also made substantial commitments to the clinical research activities of the ICTS. These additional resources coupled with the existing high quality programs in clinical and translational science ensure that WU will make outstanding contributions to this NIH initiative.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1RR024992-05
Application #
8365111
Study Section
Special Emphasis Panel (ZRR1-CR-1 (02))
Project Start
2011-06-01
Project End
2012-06-26
Budget Start
2011-06-01
Budget End
2012-06-26
Support Year
5
Fiscal Year
2011
Total Cost
$1,683,177
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Merriwether, Ericka N; Hastings, Mary K; Bohnert, Kathryn L et al. (2016) Impact of foot progression angle modification on plantar loading in individuals with diabetes mellitus and peripheral neuropathy. Edorium J Disabil Rehabil 2:15-23
Weiss, Edward P; Reeds, Dominic N; Ezekiel, Uthayashanker R et al. (2016) Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity. Endocrine :
Nicol, Ginger E; Kolko, Rachel P; Mills, Monica et al. (2016) Behavioral Weight Loss Treatment in Antipsychotic Treated Youth. Scand J Child Adolesc Psychiatr Psychol 4:96-104
Yang, Ling; Licastro, Danilo; Cava, Edda et al. (2016) Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Rep 14:422-8
Simpson, Kathleen E; Storch, Gregory A; Lee, Caroline K et al. (2016) High Frequency of Detection by PCR of Viral Nucleic Acid in The Blood of Infants Presenting with Clinical Myocarditis. Pediatr Cardiol 37:399-404
Klingensmith, Georgeanna J; Pyle, Laura; Nadeau, Kristen J et al. (2016) Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience. Diabetes Care 39:122-9
Druley, Todd E; Wang, Lihua; Lin, Shiow J et al. (2016) Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study. BMC Geriatr 16:80
Magkos, Faidon; Bradley, David; Eagon, J Christopher et al. (2016) Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on gastrointestinal metabolism of ingested glucose. Am J Clin Nutr 103:61-5
Lugar, Heather M; Koller, Jonathan M; Rutlin, Jerrel et al. (2016) Neuroimaging evidence of deficient axon myelination in Wolfram syndrome. Sci Rep 6:21167
Rodebaugh, Thomas L; Scullin, Rachel B; Langer, Julia K et al. (2016) Unreliability as a threat to understanding psychopathology: The cautionary tale of attentional bias. J Abnorm Psychol 125:840-51

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