TThe National institutes of Health's RFA for Clinical and Translational Science Awards has catalyzed the efforts of academic medical institutions to remove impediments to the translation of fundamental discoveries into better health for our citizens and rectify shortages within the clinical and translational workforce. This proposal of the Clinical and Translational Science Institute of Southeast Wisconsin is tailored to the needs and resources of the biomedical enterprise in the region and offers a novel and transformative plan to achieve the above mentioned goals. Building on the long collaborative history among the major academic and healthcare institutions in our area, we have constructed a unique academic-community partnership comprised of the Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Froedtert Hospital, Children's Hospital of Wisconsin, Zablocki VA Medical Center and BloodCenter of Wisconsin, set in the milieu of a large urban community with remarkable ethnic and social diversity. Our proposal brings together the various resources of the partner institutions to identify and address the obstacles that impede the conduct of clinical and translational research in the region. The transforming environment of our CTSI focuses on the interdependency and interrelationship of our research teams and the relationship of the key functions to the rest of the CTSA in their integrating, enabling and effecting roles. To accomplish this transformation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct 'Academic Home' for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) - which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench to bedside (T1), to clinical practices (T2), and to our communities (T3); 2) To increase the number of investigators participating in clinical research through innovative programs within the CTSI; 3) To develop, align, and coordinate infrastructure across institutions to provide our scientists with the resources required for Clinical and Translational research; and 4) To engage clinical practices and the community in research h that enhances public health. Our Community Engagement program is an MCW strength. We will build on an existing network of the Healthier Wisconsin Partnership Program (HWPP) and expertise and resources of our partners in medical, biomedical engineering, dentistry, nursing, social sciences and allied health disiciplines to implement novel community based (T3) research programs. We believe our CTSA model is transferable to other similarly-sized academic research communities across the country.
Better preventive measures, more accurate diagnostics, and more effective therapies are badly needed to improve the health of our citizens. This application provides a novel and comprehensive mechanism to address these needs through research and education. It creates a borderless, collaborative environment in SE Wisconsin for biomedical researchers, healthcare providers, educators, citizens, and industry to work together synergistically and translate the fundamental discoveries into better health for our citizens.
|Cabrera, Susanne M; Engle, Samuel; Kaldunski, Mary et al. (2018) Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes. Diabetologia 61:2356-2370|
|Lancaster, Melissa A; Meier, Timothy B; Olson, Daniel V et al. (2018) Chronic differences in white matter integrity following sport-related concussion as measured by diffusion MRI: 6-Month follow-up. Hum Brain Mapp 39:4276-4289|
|Warren, Clinton C; Young, Jonathon B; Goldberg, Mara R et al. (2018) Findings in Persistent Retinopathy of Prematurity. Ophthalmic Surg Lasers Imaging Retina 49:497-503|
|Beyer, Kirsten M M; Szabo, Aniko; Hoormann, Kelly et al. (2018) Time spent outdoors, activity levels, and chronic disease among American adults. J Behav Med 41:494-503|
|Koch, K M; Meier, T B; Karr, R et al. (2018) Quantitative Susceptibility Mapping after Sports-Related Concussion. AJNR Am J Neuroradiol 39:1215-1221|
|Avallone, Michael A; Sack, Bryan S; El-Arabi, Ahmad et al. (2017) Ten-Year Review of Perioperative Complications After Transurethral Resection of Bladder Tumors: Analysis of Monopolar and Plasmakinetic Bipolar Cases. J Endourol 31:767-773|
|Nelson, Lindsay D; Loman, Michelle M; LaRoche, Ashley A et al. (2017) Baseline Performance and Psychometric Properties of the Child Sport Concussion Assessment Tool 3 (Child-SCAT3) in 5- to 13-year-old Athletes. Clin J Sport Med 27:381-387|
|Densmore, John C; Schaid, Terry R; Jeziorczak, Paul M et al. (2017) Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. Exp Lung Res 43:38-48|
|Albert, Carolyne; Jameson, John; Tarima, Sergey et al. (2017) Macroscopic anisotropic bone material properties in children with severe osteogenesis imperfecta. J Biomech 64:103-111|
|Choi, J; Ye, S; Eng, K H et al. (2017) IPI59: An Actionable Biomarker to Improve Treatment Response in Serous Ovarian Carcinoma Patients. Stat Biosci 9:1-12|
Showing the most recent 10 out of 222 publications