This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This is the second resubmission application for a Clinical and Translational Science Award. We describe Penn State University's plan to transform our health research and education enterprise through the work of the Penn State Clinical and Translational Science Institute (CTSI). Throughout the University, the CTSI initiative has been greeted with great enthusiasm, broad support across colleges and campuses, and reaffirmation of our responsibility as a land grant University. The overarching goal of the Penn State CTSI is an engaged and responsive health science research and education enterprise that delivers on the promise of improved health. Starting with unique strengths in relevant biological, social and physical sciences, a culture and organizational structure that encourages collaboration across units, a tradition of engaging in problem-driven research, and strong connections to communities throughout Pennsylvania, we plan to achieve this by: 1) bolstering community alliances to strengthen trust, enhance awareness of disparities and ascertain needs;2) cultivating new problem-driven interdisciplinary collaborations that go well beyond the traditional boundaries of biomedicine to address these needs, including partnering with industry;3) sharing resources and promoting their most proficient use;4) capitalizing on novel tools in information technology to collect, share and mine data, anci disseminate new knowledge;and 5) educating a new generation of investigators, health professionals and community leaders who are fluent across disciplines, aware of ethical principles, sensitive to the community's needs, and able to apply their skills in partnership with others. Penn State has a rich track record of breaking down barriers and of strong support for interdisciplinary collaboration, and has committed major resources to the CTSI. In this amended application, a new leadership team in biomedical informatics has been empowered to expand infrastructure and develop new software solutions to study genetics, epigenetics and systems biology. The University has increased its already substantial health science investment in transformational technologies, innovative educational programs, and major interdisciplinary pilot project programs. Jointly with our community partners, and through the CTSA consortium, the Penn State CTSI will serve as a collaborative engine that will drive research initiatives geared to enhance wellness and better predict, preempt and treat disease in the people we serve.

Public Health Relevance

;This proposal describes the newly created Penn State Clinical and Translational Science Institute (CTSI). The overarching goal of our CTSI initiative is to revitalize the health science research and education enterprise at our University to better enable it to deliver on the promise of improved health.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1RR033184-01
Application #
8365251
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Project Start
2011-06-01
Project End
2012-02-29
Budget Start
2011-06-01
Budget End
2012-02-29
Support Year
1
Fiscal Year
2011
Total Cost
$3,051,236
Indirect Cost
Name
Pennsylvania State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Gaines, Jordan; Vgontzas, Alexandros N; Fernandez-Mendoza, Julio et al. (2018) Obstructive sleep apnea and the metabolic syndrome: The road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment. Sleep Med Rev 42:211-219
Vasilevsky, Nicole A; Foster, Erin D; Engelstad, Mark E et al. (2018) Plain-language medical vocabulary for precision diagnosis. Nat Genet 50:474-476
Fernandez-Mendoza, Julio; Li, Yun; Fang, Jidong et al. (2018) Childhood high-frequency EEG activity during sleep is associated with incident insomnia symptoms in adolescence. J Child Psychol Psychiatry :
Lewis, Mechelle M; Du, Guangwei; Baccon, Jennifer et al. (2018) Susceptibility MRI captures nigral pathology in patients with parkinsonian syndromes. Mov Disord 33:1432-1439
Li, Qunhua; Zhang, Feipeng (2018) A regression framework for assessing covariate effects on the reproducibility of high-throughput experiments. Biometrics 74:803-813
Lee, Eun-Young; Flynn, Michael R; Lewis, Mechelle M et al. (2018) Welding-related brain and functional changes in welders with chronic and low-level exposure. Neurotoxicology 64:50-59
Mukherjee, Dahlia; Krishnamurthy, Venkatesh Bassapa; Millett, Caitlin E et al. (2018) Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder. Bipolar Disord 20:27-34
Du, Guangwei; Lewis, Mechelle M; Sica, Christopher et al. (2018) Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients. Mov Disord 33:1423-1431
Frye, S S; Fernandez-Mendoza, J; Calhoun, S L et al. (2018) Neurocognitive and behavioral functioning in adolescents with sleep-disordered breathing: a population-based, dual-energy X-ray absorptiometry study. Int J Obes (Lond) 42:95-101
Gorsic, Lidija K; Kosova, Gulum; Werstein, Brian et al. (2017) Pathogenic Anti-Müllerian Hormone Variants in Polycystic Ovary Syndrome. J Clin Endocrinol Metab 102:2862-2872

Showing the most recent 10 out of 95 publications