The University of Pittsburgh is uniquely suited, committed, and obligated to transform its academic culture, environment, and structure to further promote clinical and translational science as a distinct discipline locally and nationally. The University's Clinical and Translational Science Institute (CTSI) was founded in 2006 to lead an unprecedented inter-institutional initiative to achieve this goal. Over the past four years, CTSI revolutionized the University's research enterprise to develop, nurture, and support a new cadre of highly trained clinical and translational scientists and to enable their innovative research. Through novel institutional integration of pre-CTSA programs and the development of new interdisciplinary research and training initiatives, CTSI enabled our scientists to excel in generating new biomedical knowledge and translating this knowledge bidirectionally across the entire translational research spectrum. Our systematic approach to CTSI is based on an evolutionary transformation process that continuously evaluates programmatic outcomes, builds on past and current activities to create new and modify existing plans, and guides the evolution of CTSI's overarching goals. This dynamic approach resulted in the development of myriad infrastructure, programs, and services in ten CTSI Cores. It also serves as the basis for managing CTSI's next period of evolutionary growth. Over the next five years, we will: 1) transform our institution through an integrative collaborative approach to coalesce clinical and translational research and education programs, 2) transform our scientists through competency-based educational programs and the infusion of mentoring into all levels of training to advance the field of clinical and translational science through the next generation, 3) transform research by providing a robust resource environment to support team science and through the development of mechanisms for data sharing, and 4) transform health practice and the community through participatory partnerships that permit the full scope of bi-directional research translation. These transformations will lead to fundamental changes at the University of Pittsburgh that will enable CTSI faculty and investigators to conduct visionary, relevant clinical and translational research.

Public Health Relevance

By establishing clinical and translational science as a distinct discipline, CTSI's focus is on moving actionable research findings into practice and prevention settings, improving health at the individual and population levels. CTSI's outreach using a community based participatory research model enables citizens to partner with CTSI to identify and address their own health care needs using sound public health principles.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR000005-09S2
Application #
8917355
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Brazhnik, Olga
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2014-09-09
Budget End
2015-03-08
Support Year
9
Fiscal Year
2014
Total Cost
$115,500
Indirect Cost
$40,500
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Davison, Jon M; Landau, Michael S; Luketich, James D et al. (2016) A Model Based on Pathologic Features of Superficial Esophageal Adenocarcinoma Complements Clinical Node Staging in Determining Risk of Metastasis to Lymph Nodes. Clin Gastroenterol Hepatol 14:369-377.e3
Insana, Salvatore P; Banihashemi, Layla; Herringa, Ryan J et al. (2016) Childhood maltreatment is associated with altered frontolimbic neurobiological activity during wakefulness in adulthood. Dev Psychopathol 28:551-64
Simons, Jeffrey P; Greenberg, Laura L; Mehta, Deepak K et al. (2016) Laryngomalacia and swallowing function in children. Laryngoscope 126:478-84
Sink, Jacquelyn R; Kitsko, Dennis J; Mehta, Deepak K et al. (2016) Diagnosis of Pediatric Foreign Body Ingestion: Clinical Presentation, Physical Examination, and Radiologic Findings. Ann Otol Rhinol Laryngol 125:342-50
Taylor, Briana J; Matthews, Karen A; Hasler, Brant P et al. (2016) Bedtime Variability and Metabolic Health in Midlife Women: The SWAN Sleep Study. Sleep 39:457-65
Lee, B; Diaz, G A; Rhead, W et al. (2016) Glutamine and hyperammonemic crises in patients with urea cycle disorders. Mol Genet Metab 117:27-32
Tillman, Bryan W; Chun, Youngjae; Cho, Sung Kwon et al. (2016) Dual chamber stent prevents organ malperfusion in a model of donation after cardiac death. Surgery 160:892-901
Leader, Joseph K; Crothers, Kristina; Huang, Laurence et al. (2016) Risk Factors Associated With Quantitative Evidence of Lung Emphysema and Fibrosis in an HIV-Infected Cohort. J Acquir Immune Defic Syndr 71:420-7
Vanyukov, P M; Szanto, K; Hallquist, M N et al. (2016) Paralimbic and lateral prefrontal encoding of reward value during intertemporal choice in attempted suicide. Psychol Med 46:381-91
Kwon, Soyang; Janz, Kathleen F; Letuchy, Elena M et al. (2016) Parental characteristic patterns associated with maintaining healthy physical activity behavior during childhood and adolescence. Int J Behav Nutr Phys Act 13:58

Showing the most recent 10 out of 2317 publications