The goal of The Rockefeller University Center for Clinical and Translational Science is to improve human health by: 1. providing an infrastructure to conduct clinical investigation at the highest level, educational programs to train future generations of skilled and committed investigators, and novel methods of clinical investigation that can be shared with others, and 2. working closely with other CTSA institutions to set national standards so as to improve the conduct of clinical research. The 2006 Clinical and Translational Science Award transformed translational research at Rockefeller University and we propose to build on these accomplishments by: 1) enhancing our KL2 Master's degree and Certificate in Clinical and Translational Science educational programs;2) creating a new educational program for our current K08 and K23 awardees to speed their transition to scientific independence;3) expanding our bidirectional community engaged research with our partner institutions, integrating molecular mechanistic and population-based components, 4) completing the implementation of our integrated, customized information technology infrastructure to facilitate protocol development, review, and conduct;5) implementing a novel real-time monitoring system to insure compliance with Good Clinical Practice;6) enhancing our multi-disciplinary and multi-departmental Protocol Navigation program to speed protocol development, approval, and implementation, and extending it to bidirectional community engaged research;7) expanding the application of novel nonparametric biostatistical methods to genomic and community-based investigation;8) utilizing our new deep human phenotyping systems to aid scientific discovery and address important clinical needs;9) utilizing a validated measure of research participants'perceptions to improve the conduct of clinical research;and 10) continuing to actively participate in the national CTSA consortium to advance the discipline of clinical and translational science for the benefit of human health.
The Rockefeller University Center for Clinical and Translational Science is dedicated to improving human health by providing the resources and personnel to conduct the highest quality research to improve the prevention, diagnosis, and treatment of human disease. It also is producing novel methods to improve the scientific information obtained from clinical research studies and the way in which the research is performed.
|Bozzacco, Leonia; Yi, Zhigang; Andreo, Ursula et al. (2016) Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication. J Virol 90:3212-28|
|Gristick, Harry B; von Boehmer, Lotta; West Jr, Anthony P et al. (2016) Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat Struct Mol Biol 23:906-915|
|Lau, T; Bigio, B; Zelli, D et al. (2016) Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. Mol Psychiatry :|
|Pereira, A C; Gray, J D; Kogan, J F et al. (2016) Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole. Mol Psychiatry :|
|Markowitz, Martin; Deren, Sherry; Cleland, Charles et al. (2016) Chronic Hepatitis C Virus Infection and the Proinflammatory Effects of Injection Drug Use. J Infect Dis 214:1376-1382|
|Karaca, N E; Aksu, G; Ulusoy, E et al. (2016) Disseminated BCG Infectious Disease and Hyperferritinemia in a Patient With a Novel NEMO Mutation. J Investig Allergol Clin Immunol 26:268-71|
|Ponda, Manish P; Breslow, Jan L (2016) Serum stimulation of CCR7 chemotaxis due to coagulation factor XIIa-dependent production of high-molecular-weight kininogen domain 5. Proc Natl Acad Sci U S A :|
|Donovan, Frank X; Kimble, Danielle C; Kim, Yonghwan et al. (2016) Paternal or Maternal Uniparental Disomy of Chromosome 16 Resulting in Homozygosity of a Mutant Allele Causes Fanconi Anemia. Hum Mutat 37:465-8|
|Bigio, Benedetta; MathÃ©, Aleksander A; Sousa, Vasco C et al. (2016) Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance. Proc Natl Acad Sci U S A 113:7906-11|
|Evering, Teresa H; Applebaum, Allison; La Mar, Melissa et al. (2016) Rates of non-confounded HIV-associated neurocognitive disorders in men initiating combination antiretroviral therapy during primary infection. AIDS 30:203-10|
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