At the University of Kentucky (UK), we have established the Center for Clinical and Translational Science (CCTS) as a home for clinical and translational research. UK is located in Lexington, on the western edge of mid-Appalachia, one ofthe poorest areas ofthe country, where there are unprecedented disparities in disease and mortality. Many of these disparities stem from risky behaviors, such as smoking, drug abuse, and obesity. In this proposal, our overarching goal is to transform the pace, effectiveness, and quality of translational research at UK which will result in better health for the people of mid-Appalachia. Scientific discovery offers the potential for improved care, with community-based research offering a faster impact on health through a better dissemination of optimal medical care. However, scientific discoveries often do not reach the community due to the many difficulties with navigating the complex process of clinical and translational research. In this application, we will capitalize on our strengths in education, basic and clinical sciences, as well as our outstanding programs in practice- and community- based participatory research. These efforts will result in scientific discovery that will impact the health ofthe Appalachian rural community in the near term, and prime the pipeline for the future. To accomplish these goals, UK will form a collaboration with Marshall University, which is 2 hr away in Huntington, WV. In addition, we will form an Appalachian Translational Reseach Network involving not only Marshall, but also the CTSAs at the Ohio State University, University of Cinncinati, Morehead University, and Pikeville School of Osteopathic Medicine. This network will be especially important in the further development of our strong programs in community based participatory research. To help integrate our efforts, we have developed an innovative group of faculty CATalysts, who will build collaborative team science programs backed by generous pilot funding that will target novel ideas at all levels of science. New CCTS programs in """"""""Drug Development"""""""", """"""""Novel Methodologies"""""""", and """"""""Risk-Related Behavior Research"""""""" will capitalize on our strengths, engage investigators with diverse areas of expertise, and will more quickly impact the health of the Appalachian community. We have recently recruited a new leader in Biomedical Informatics and have invested heavily in this program, which will greatly improve our ability to transform data into knowledge throughout the CCTS. Through these initiatives, UK will fulfill its mandate as Kentucky's flagship university to improve the health of Central Appalachia, and thereby add unique value to improvements in the health ofthe nation.
The CCTS at UK has developed well-integrated relationships with University programs in Central Appalachia and with rural health programs. We routinely apply a foundation principal of community based participatory research, where the lay community identifies ttie research issues and co-develops solutions. This proposal seeks to make research more relevant by breaking down bamers to research translation and greatly improving the pace by which science discoveries drive improvements in health in Kentucky and the nation.
|Ebersole, J L; Kirakodu, S; Novak, M J et al. (2016) Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol 31:18-32|
|Pumphrey, Ashley; Yang, Zhengshi; Ye, Shaojing et al. (2016) Advanced cardiac chemical exchange saturation transfer (cardioCEST) MRI for in vivo cell tracking and metabolic imaging. NMR Biomed 29:74-83|
|Walsh, Sharon L; Nuzzo, Paul A; Babalonis, Shanna et al. (2016) Intranasal buprenorphine alone and in combination with naloxone: Abuse liability and reinforcing efficacy in physically dependent opioid abusers. Drug Alcohol Depend 162:190-8|
|Wicker, Christina A; Izumi, Tadahide (2016) Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components. BMC Genomics 17:983|
|Cao, Hongnan; Tan, Kemin; Wang, Fengbin et al. (2016) Structural dynamics of a methionine Î³-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate. Struct Dyn 3:034702|
|Huang, Chifu B; Alimova, Yelena; Ebersole, Jeffrey L (2016) Macrophage polarization in response to oral commensals and pathogens. Pathog Dis 74:|
|Powell, Elizabeth Salmon; Carrico, Cheryl; Raithatha, Ravi et al. (2016) Transvertebral direct current stimulation paired with locomotor training in chronic spinal cord injury: A case study. NeuroRehabilitation 38:27-35|
|Wu, Chia-Hua; Mohammadmoradi, Shayan; Thompson, Joel et al. (2016) Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice. Hypertension 68:213-9|
|Elpers, Julia; Lester, Cathy; Shinn, Jennifer B et al. (2016) Rural Family Perspectives and Experiences with Early Infant Hearing Detection and Intervention: A Qualitative Study. J Community Health 41:226-33|
|Kirby, Tyler J; Walton, R Grace; Finlin, Brian et al. (2016) Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue. Physiol Genomics 48:145-53|
Showing the most recent 10 out of 437 publications