This is the second resubmission application for a Clinical and Translational Science Award. We describe Penn State University's plan to transform our health research and education enterprise through the work of the Penn State Clinical and Translational Science Institute (CTSI). Throughout the University, the CTSI initiative has been greeted with great enthusiasm, broad support across colleges and campuses, and reaffirmation of our responsibility as a land grant University. The overarching goal of the Penn State CTSI is an engaged and responsive health science research and education enterprise that delivers on the promise of improved health. Starting with unique strengths in relevant biological, social and physical sciences, a culture and organizational structure that encourages collaboration across units, a tradition of engaging in problem-driven research, and strong connections to communities throughout Pennsylvania, we plan to achieve this by: 1) bolstering community alliances to strengthen trust, enhance awareness of disparities and ascertain needs;2) cultivating new problem-driven interdisciplinary collaborations that go well beyond the traditional boundaries of biomedicine to address these needs, including partnering with industry;3) sharing resources and promoting their most proficient use;4) capitalizing on novel tools in information technology to collect, share and mine data, anci disseminate new knowledge;and 5) educating a new generation of investigators, health professionals and community leaders who are fluent across disciplines, aware of ethical principles, sensitive to the community's needs, and able to apply their skills in partnership with others. Penn State has a rich track record of breaking down barriers and of strong support for interdisciplinary collaboration, and has committed major resources to the CTSI. In this amended application, a new leadership team in biomedical informatics has been empowered to expand infrastructure and develop new software solutions to study genetics, epigenetics and systems biology. The University has increased its already substantial health science investment in transformational technologies, innovative educational programs, and major interdisciplinary pilot project programs. Jointly with our community partners, and through the CTSA consortium, the Penn State CTSI will serve as a collaborative engine that will drive research initiatives geared to enhance wellness and better predict, preempt and treat disease in the people we serve.
; This proposal describes the newly created Penn State Clinical and Translational Science Institute (CTSI). The overarching goal of our CTSI initiative is to revitalize the health science research and education enterprise at our University to better enable it to deliver on the promise of improved health.
|Du, Guangwei; Lewis, Mechelle M; Sica, Christopher et al. (2018) Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease. Ann Neurol :|
|Miller, Amanda J; Luck, J Carter; Kim, Danielle Jin-Kwang et al. (2018) Peripheral revascularization attenuates the exercise pressor reflex and increases coronary exercise hyperemia in peripheral arterial disease. J Appl Physiol (1985) 125:58-63|
|Fu, Guifang; Huang, Mian; Bo, Wenhao et al. (2018) Mapping morphological shape as a high-dimensional functional curve. Brief Bioinform 19:461-471|
|Vargas Pelaez, Alvaro F; Ramirez, Sarah I; Valdes Sanchez, Chavely et al. (2018) Implementing a medical student interpreter training program as a strategy to developing humanism. BMC Med Educ 18:141|
|Buss, Kristin A; Davis, Elizabeth L; Ram, Nilam et al. (2018) Dysregulated Fear, Social Inhibition, and Respiratory Sinus Arrhythmia: A Replication and Extension. Child Dev 89:e214-e228|
|Abbott, Katherine M; Heid, Allison R; Kleban, Morton et al. (2018) The Change in Nursing Home Residents' Preferences Over Time. J Am Med Dir Assoc 19:1092-1098|
|Evans-Hoeker, Emily A; Eisenberg, Esther; Diamond, Michael P et al. (2018) Major depression, antidepressant use, and male and female fertility. Fertil Steril 109:879-887|
|Lee, Eun-Young; Flynn, Michael R; Lewis, Mechelle M et al. (2018) Welding-related brain and functional changes in welders with chronic and low-level exposure. Neurotoxicology 64:50-59|
|Symons Downs, Danielle; Savage, Jennifer S; Rivera, Daniel E et al. (2018) Individually Tailored, Adaptive Intervention to Manage Gestational Weight Gain: Protocol for a Randomized Controlled Trial in Women With Overweight and Obesity. JMIR Res Protoc 7:e150|
|Keller, Kathleen L; English, Laural K; Fearnbach, S Nicole et al. (2018) Brain response to food cues varying in portion size is associated with individual differences in the portion size effect in children. Appetite 125:139-151|
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