The Yale Center for Clinical Investigation (YCCI) was created to provide a """"""""home"""""""" for training the next generation of clinical investigators. Key programmatic goals are to 1) attract highly talented students and junior faculty across medicine, nursing, public health, biological sciences and biomedical engineering;and train them in the use of state-of-the-art research tools;give them the skills to work within complex research teams;and support their professional development;and 2) foster the translation of disease-related discoveries from the laboratory into the clinic and then the community by: stimulating the creation of interdisciplinary teams;making available state-of-the-art core facilities and expanded biostatistical and bioinformatics resources;establishing organizational and regulatory infrastructure for clinical studies;and forging new partnerships that will integrate community leaders, physicians, and health centers and encourage participation in research. Participating institutions include the Schools of Medicine, Nursing, and Public Health, the department of Biomedical Engineering and the Graduate Programs in Biological and Biomedical Sciences. The Junior Faculty Scholars award program and the Investigative Medicine program (IMP) are central to YCCI's education and training efforts. IMP is a unique doctoral program that offers Ph.D. degrees in Health Sciences Research to highly qualified M.D. fellows embarking on careers in translational or clinical research and the junior faculty scholars program is a career development program. YCCI has also created a Society of Mentors who participates actively in the training and nurturing of the YCCI Scholars. Pilot and feasibility (P&F) grants will be awarded for: 1) interdisciplinary translational team research;2) development of novel methodologies;3) Use of Core (incl imaging) technologies;and 4) community-based research. YCCI will cluster research cores around common themes, including: imaging;genomics and proteomics;cell and tissue based tech;Integrated metabolics;cognition and biobehavior;and animal models. The Office of Research Services will provide robust facilities and resources for regulatory, biostatistical, bioinformatics, recruitment and other support services. YCCI will have an office to coordinate the University's efforts to address health issues facing our community and our national community.
This research has direct relevance to public health in that its goals are to facilitate clinical research, including by training the next generation of clinical researchers that will lead to better treatments for human disease and better health outcomes.
|Perkins, Susan M; Bacchetti, Peter; Davey, Cynthia S et al. (2016) Best Practices for Biostatistical Consultation and Collaboration in Academic Health Centers. Am Stat 70:187-194|
|Wang, Clinton; Schwan, Jonas; Campbell, Stuart G (2016) Slowing of contractile kinetics by myosin-binding protein C can be explained by its cooperative binding to the thin filament. J Mol Cell Cardiol 96:2-10|
|Li, Simon; Silva, Cicero T; Brudnicki, Adele R et al. (2016) Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children. Pediatr Radiol 46:219-28|
|Wong, Daniel J; Lu, Daniel Y; Protack, Clinton D et al. (2016) Ephrin type-B receptor 4 activation reduces neointimal hyperplasia in human saphenous vein inÂ vitro. J Vasc Surg 63:795-804|
|Knobf, M Tish; Jeon, Sangchoon; Smith, Barbara et al. (2016) Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy. Breast Cancer Res Treat 155:491-500|
|Boyden, Lynn M; Kam, Chen Y; HernÃ¡ndez-MartÃn, Angela et al. (2016) Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome. Hum Mol Genet 25:348-57|
|Fineberg, S K; Corlett, P R (2016) The doxastic shear pin: delusions as errors of learning and memory. Cogn Neuropsychiatry 21:73-89|
|Clarke, Toni-Kim; Smith, Andrew H; Gelernter, Joel et al. (2016) Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addict Biol 21:469-80|
|Belinsky, Glenn S; Sreekumar, Bharath; Andrejecsk, Jillian W et al. (2016) Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade. FASEB J 30:2837-48|
|Lennington, Jessica B; Coppola, Gianfilippo; Kataoka-Sasaki, Yuko et al. (2016) Transcriptome Analysis of the Human Striatum in Tourette Syndrome. Biol Psychiatry 79:372-82|
Showing the most recent 10 out of 658 publications