Applying for our second CTSA, Tufts Clinical and Translational Science Institute (CTSl) remains avidly committed to involving the full spectrum of clinical ahd translational research (CTR) to meet the pnsmise of biomedical science, not only bench to bedside (T1) translation, crucial to having health impact, translation into effective clinical practice (T2), care delivery and public health (TS), and health policy ('T4). In 2008 we started Tufts CTSl building on prior CTR resources, services, and educational programs, we purposely selected partners that would leverage and complement each other's special assets. Our 38 strategically- chosen partners Include 12 Tufts University schools/research centers, ten Tufts hospitals, three academic institutions (Brandeis University, Northeastern University, RAND Corporation), eight community-based organizations, and five industry partners, an outstanding and synergistic resources, opportunities, and education across the T1-T4 spectrum. Described in our application's four sections are four aims that build on this platform:
AIM 1 : Strengthen Tufts CTSl overall by: 1) organizing and leading its partners in their commitment to this shared home for CTR; 2) expanding efficient access for all partners to a full spectrum of high-quality resources in a way that promotes collaborative CTR across disciplines and institutionsjS) advancing the field of CTR through local and national leadership and development of novel methods;4) providing innovative and tai^eted education and training across the T1-4 spectmm. (Section I) AIM 2: Operationalize and implement the CTR home and its infra- stnjcture, sen/ices and programs, including its central office personnel, administrative and financial management systems, committees, and other necessary structures. (Section II) AIM 3: Sustain and grow innovative resources, services, and policies that support and promote collaborative, cross-disciplinary, full-spectrum translational research. (Section III) AIM 4: Develop and broaden the CTR workforce through education and training across the T1-T4 spectrum, with a specific focus on addressing translational gaps between bench to bedside and from bedside to widespread impact on health. (Section IV)

Public Health Relevance

(See Instmctions): Tufts Clinical and Translational Science Institute uses the entire spectrum of clinical and translational research (CTR) to help meet the promise and the public's needs of biomedical science.This includes bench to bedside (Tl) translation and crucially for having health impact, translation into effective clinical practice (T2), care delivery and public health (TS-), and health policy (?T4).

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR001064-04S1
Application #
9349932
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Wilde, David B
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2016-09-24
Budget End
2017-04-30
Support Year
4
Fiscal Year
2016
Total Cost
$620,603
Indirect Cost
$141,612
Name
Tufts University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Leyenaar, JoAnna K; Shieh, Meng-Shiou; Lagu, Tara et al. (2018) Hospital and Community Characteristics Associated With Pediatric Direct Admission to Hospital. Acad Pediatr 18:525-534
Mirhashemi, Marzieh Ezzaty; Noubary, Farzad; Chapman-Bonofiglio, Susan et al. (2018) Transcriptome analysis of pig intestinal cell monolayers infected with Cryptosporidium parvum asexual stages. Parasit Vectors 11:176
Beddhu, Srinivasan; Chertow, Glenn M; Cheung, Alfred K et al. (2018) Influence of Baseline Diastolic Blood Pressure on Effects of Intensive Compared With Standard Blood Pressure Control. Circulation 137:134-143
Bent, Daniel P; Nelson, Jason; Kent, David M et al. (2018) Population-Based Validation of a Clinical Prediction Model for Congenital Diaphragmatic Hernias. J Pediatr 201:160-165.e1
Wolfe, Elizabeth Suzanne; Arabian, Sandra Strack; Breeze, Janis L et al. (2018) Evaluating the Effectiveness of the Translated ""A Matter of Balance"" Fall Prevention Program Materials for Non-English-Speaking Participants. J Trauma Nurs 25:311-317
Dobre, Mirela; Gaussoin, Sarah A; Bates, Jeffrey T et al. (2018) Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults. Clin J Am Soc Nephrol 13:596-603
Lee, A C; Harvey, W F; Han, X et al. (2018) Pain and functional trajectories in symptomatic knee osteoarthritis over up to 12 weeks of exercise exposure. Osteoarthritis Cartilage 26:501-512
Nowak, Kristen L; You, Zhiying; Gitomer, Berenice et al. (2018) Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol 29:571-578
Dad, Taimur; Tighiouart, Hocine; Lacson Jr, Eduardo et al. (2018) Hemodialysis patient characteristics associated with better experience as measured by the In-center Hemodialysis Consumer Assessment of Healthcare Providers and Systems (ICH CAHPS) survey. BMC Nephrol 19:340
Schoenfeld, Elizabeth M; Kanzaria, Hemal K; Quigley, Denise D et al. (2018) Patient Preferences Regarding Shared Decision Making in the Emergency Department: Findings From a Multisite Survey. Acad Emerg Med 25:1118-1128

Showing the most recent 10 out of 201 publications