One of medicine's greatest cirallenges today is the efficient, seamless and safe translation of biomedical research discoveries into clinical applications that improve human health. New methodologies, technologies and integrated information systems offer unprecedented promise for discovery and growth of translational successes;however significant barriers continue to confound our ability to rapidly move discoveries into clinical practice, including the efficiency, cost and effectiveness of our research processes. The Colorado Clinical and Translational Sciences Institute (CCTSI), created in 2008, has addressed these challenges and transformed our institutional research infrastructure. In this application, the University of Colorado Denver (CU-D) and our partner institutions (CU-Boulder and Colorado State University [CSU], six major hospitals and health care organizations and local communities) will re-engineer the CCTSI through the following five Strategic Goals: 1) Enrich and expand our integrated statewide academic home for clinical and translational research. 2) Institute new clinical research management strategies to strengthen quality, safety, efficiency, cost effectiveness and innovative team science, including implementing new software systems and work flows. 3) Centralize and enhance the delivery of our outstanding resources, services and technologies and institute charge-backs to investigators where appropriate. 4) Infuse key concepts of community engagement into the full spectrum of translational research. 5) Increase the translational research workforce capacity through a broad curriculum of education, training and career development opportunities. A rigorous tracking, assessment and evaluation program coupled to a formal quality and process improvement program embedded in the CCCTSI will ensure the most efficient, cost-effective, and innovative use of our precious resources, while protecting the safety of our study participants. These programs will be centralized at one of the newest biomedical research, education and clinical enterprises in the nation, the CU Anschutz Medical Campus in which adjacencies of our schools, research laboratories, three hospitals and a biomedical corporate park create the ideal environment for our success.

Public Health Relevance

The relevance of this project to public health lies in our ability to help researchers take important discoveries and translate them into new treatments, preventions and cures for human diseases. We also will help researchers find ways to bring these therapies into the community setting to benefit people across our state and country.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR001082-02
Application #
8743337
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Purucker, Mary E
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
$12,564,400
Indirect Cost
$2,090,747
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Libby, Anne M; Ingbar, David H; Nearing, Kathryn A et al. (2018) Developing senior leadership for clinical and translational science. J Clin Transl Sci 2:124-128
Majtan, Tomas; Park, Insun; Bublil, Erez M et al. (2018) Enzyme replacement therapy prevents loss of bone and fat mass in murine homocystinuria. Hum Mutat 39:210-218
Loomes, Kathleen M; Spino, Cathie; Goodrich, Nathan P et al. (2018) Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Hepatology :
VanderKooy, Timothy; Spaur, Kelsey; Brou, Lina et al. (2018) Utilization of Intravenous Catheters by Prehospital Providers during Pediatric Transports. Prehosp Emerg Care 22:50-57
Chiang, David; Chen, Xintong; Jones, Stacie M et al. (2018) Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TH2 subsets. J Allergy Clin Immunol 141:2107-2120
Melanson, Edward L; Lyden, Kate; Gibbons, Ellie et al. (2018) Influence of Estradiol Status on Physical Activity in Premenopausal Women. Med Sci Sports Exerc 50:1704-1709
Simon, Stacey L; Vigers, Tim; Campbell, Kristen et al. (2018) Reduced insulin sensitivity is correlated with impaired sleep in adolescents with cystic fibrosis. Pediatr Diabetes 19:1183-1190
Joksimovic, Sonja L; Joksimovic, Srdjan M; Tesic, Vesna et al. (2018) Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal 11:
Daoud, Ariel Kiyomi; Mandler, Tessa; Gagliardi, Alexia Georgia et al. (2018) Combined Femoral-Sciatic Nerve Block is Superior to Continuous Femoral Nerve Block During Anterior Cruciate Ligament Reconstruction in the Pediatric Population. Iowa Orthop J 38:101-106
Salami, Falastin; Lee, Hye-Seung; Freyhult, Eva et al. (2018) Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes. Diabetes 67:2329-2336

Showing the most recent 10 out of 1652 publications