To fulfill tlie new NCATS vision for the CTSA Consortium and accelerate scientific discoveries into improved outcomes for patients, academic health and science systems must invest, transform, and innovate to optimize their unique strengths. Our vision, aligned with that of NCATS, is to create a research environment at Duke that stimulates the translation of scientific discovery from bench to bedside by 1) linking discovery science to a creative engine that efficiently accelerates development of new technologies;and 2) integrating clinical trials, registries, and electronic health records in a learning health system where research and practice form a continuum. Our research environment will be driven by scientific merit and societal need, "agnostic" to disease or specialty discipline, aligned with our updated institutional framework for research oversight and quality, and continually evaluated for academic productivity, efficiency, and cost. To achieve these goals, we will create an Integrated Home for clinical and translational research by providing infrastructure and resources to serve investigators and trainees across the research spectrum. We will offer resources based upon common needs among our researchers, including education, biostatistics, biobanking, regulatory expertise, ethics, pilot funding and recruitment assistance. We will also tailor our offerings to specialized needs across research communities that include early translation, proof of concept, site-based research and population based research, which includes multi-site trials, outcomes, health services, implementation science and community engaged research. Integrating these resources will require a new tool, a portal for all trainees and investigators, MyResearchHome@Duke, and its human counterpart, MyResearchTeam@Duke. These tools will provide a single point of entry for all clinical and translational research at Duke, regardless of their department or school. Thus, we will enhance our Integrated Home for clinical and translational research with a combination of sophisticated information technology and mentoring and navigation;provide access to common and specialized resources for all of our translational research communities and train the next generation of researchers in our educational and training programs.
The CTSA will foster the translational research process, ensuring that new discoveries are developed and evaluated more quickly and that clinical research is done with high quality, efficiency, safety and cost- effectiveness.
|Gonzalez, Daniel; Palazzi, Debra L; Bhattacharya-Mithal, Leena et al. (2016) Solithromycin Pharmacokinetics in Plasma and Dried Blood Spots and Safety in Adolescents. Antimicrob Agents Chemother 60:2572-6|
|Zozus, Meredith N; Richesson, Rachel L; Walden, Anita et al. (2016) Research Reproducibility in Longitudinal Multi-Center Studies Using Data from Electronic Health Records. AMIA Jt Summits Transl Sci Proc 2016:279-85|
|Ha, Min Jin; Sun, Wei; Xie, Jichun (2016) PenPC: A two-step approach to estimate the skeletons of high-dimensional directed acyclic graphs. Biometrics 72:146-55|
|Patel, Angira; Costello, John M; Backer, Carl L et al. (2016) Prevalence of Noncardiac and Genetic Abnormalities in Neonates Undergoing Cardiac Operations: Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database. Ann Thorac Surg 102:1607-1614|
|Snyder, Denise C; Brouwer, Rebecca N; Ennis, Cory L et al. (2016) Retooling institutional support infrastructure for clinical research. Contemp Clin Trials 48:139-45|
|Ku, Lawrence C; Wu, Huali; Greenberg, Rachel G et al. (2016) Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine. Ther Drug Monit 38:728-737|
|Hornik, Christoph P; Benjamin Jr, Daniel K; Smith, P Brian et al. (2016) Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates. J Pediatr 178:125-129.e1|
|England, Amanda; Wade, Kelly; Smith, P Brian et al. (2016) Optimizing operational efficiencies in early phase trials: The Pediatric Trials Network experience. Contemp Clin Trials 47:376-82|
|DeLorenze, Gerald N; Nelson, Charlotte L; Scott, William K et al. (2016) Polymorphisms in HLA Class II Genes Are Associated With Susceptibility to Staphylococcus aureus Infection in a White Population. J Infect Dis 213:816-23|
|Park, Sunghee; Chang, Ching-Yi; Safi, Rachid et al. (2016) ERRÎ±-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer. Cell Rep 15:323-35|
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