San Antonio, the gateway to South Texas, is the 7*^ largest city in the US and the largest metropolitan area with a majority Hispanic population (63%). South Texas is about the size of Ohio, and comprises an impoverished and largely Hispanic population with disproportionate rates of diabetes and obesity, exacerbated by a lack of health insurance and poor access to health care. This region also contains numerous US military installations, and active-duty service members and veterans often have special health issues, including Increased risk for post-traumatic stress disorder and traumatic injuries. Unfortunately, neither better access to care nor improved care delivery can eliminate health disparities and meet these complex needs, in addition, research across the full T l to T4 translational spectrum is required to eliminate knowledge gaps and establish real-world effectiveness that improves health care for our populations. In 2006, UTHSCSA established the Institute for Integration of Medicine and Science (IIMS) to improve health and reduce disparities by accelerating scientific discoveries and applications across the full translational research spectrum. For example, IIMS expanded the number of clinical research units that extend to the Texas-Mexico border from 1 to 7, and dramatically increasing participant access to clinical and translational science. We increased, from 2 to 6, the Practice-Based Research Networks that focus on diverse ambulatory populations. Efforts to address translational science workforce needs over the past 5-10 years have graduated 100 Masters Clinical Investigation students, supported 19 successful KL2 Scholars, and established new joint Translational Science PhD and Certificate programs. In this proposal, we provide strategies to spur clinical and translational science evolution, catalyze research teams, and implement programs that produce creative, collaborative, and culturally diverse scientists.
Our Specific Aims will: 1. Accelerate clinical and translational research innovation and effective team science along the entire 11 to T4 research spectrum by providing an academic home integrated with our strategic partner institutions. 2. Expand, diversify, and enhance the workforce of interdisciplinary translational biomedical scientists. 3. Implement effective methods to continuously evaluate and optimize services, increase efficiencies, improve processes, and reduce costs across all IIMS programs.

Public Health Relevance

Based on our vision of improving the health status of South Texas by accelerating scientific discoveries and public health applications, we will deploy strategic resources that focus on prevalent challenges in our region, including: 1) the health needs of our underserved Hispanic population, 2) the special health issues facing active-duty military and veteran populations, and 3) limitations in the translational science workforce required to fill in critical knowledge gaps and improve health in South Texas and the US.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR001120-01
Application #
8721521
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Sawczuk, Andrea
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2013-09-26
Budget End
2014-04-30
Support Year
1
Fiscal Year
2013
Total Cost
$2,468,749
Indirect Cost
$681,130
Name
University of Texas Health Science Center San Antonio
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Jay, Colleen L; Washburn, Kenneth; Dean, Patrick G et al. (2017) Survival Benefit in Older Patients Associated With Earlier Transplant With High KDPI Kidneys. Transplantation 101:867-872
Cheng, Haili; Bao, Xin; Gan, Xin et al. (2017) Multiple E3s promote the degradation of histone H3 variant Cse4. Sci Rep 7:8565
Chrepa, Vanessa; Austah, Obadah; Diogenes, Anibal (2017) Evaluation of a Commercially Available Hyaluronic Acid Hydrogel (Restylane) as Injectable Scaffold for Dental Pulp Regeneration: An In Vitro Evaluation. J Endod 43:257-262
Savic, R M; Weiner, M; MacKenzie, W R et al. (2017) Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials. Clin Pharmacol Ther 102:321-331
Jans, Petra E; Mfuh, Adelphe M; Arman, Hadi D et al. (2017) Cytotoxicity and Mechanism of Action of the Marine-Derived Fungal Metabolite Trichodermamide B and Synthetic Analogues. J Nat Prod 80:676-683
Frei, Christopher R; Rehani, Sylvie; Lee, Grace C et al. (2017) Application of a Risk Score to Identify Older Adults with Community-Onset Pneumonia Most Likely to Benefit From Empiric Pseudomonas Therapy. Pharmacotherapy 37:195-203
Wood, Pamela R; Kampschmidt, Jordan C; Dube, Peter H et al. (2017) Mycoplasma pneumoniae and health outcomes in children with asthma. Ann Allergy Asthma Immunol 119:146-152.e2
Rahbar, Mohammad H; Dickerson, Aisha S; Ahn, Chul et al. (2017) Characteristics of Biostatistics, Epidemiology, and Research Design Programs in Institutions With Clinical and Translational Science Awards. Acad Med 92:229-236
Kellogg 3rd, Dean L; McCammon, Karen M; Hinchee-Rodriguez, Kathryn S et al. (2017) Neuronal nitric oxide synthase mediates insulin- and oxidative stress-induced glucose uptake in skeletal muscle myotubes. Free Radic Biol Med 110:261-269
Jayabal, Panneerselvam; Houghton, Peter J; Shiio, Yuzuru (2017) EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1. Genes Cancer 8:762-770

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