Contact PD/PI: Shekhar, Anantha INDIANA CLINICAL AND TRANSLATIONAL SCIENCES INSTITUTE: OVERALL SUMMARY/ABSTRACT The Indiana Clinical and Translational Sciences Institute (Indiana CTSI) was created in 2008 as a statewide laboratory to accelerate clinical and translational research by the three research universities, Indiana, Purdue and Notre Dame, with partner health care systems, local foundations and corporate partners. The mission of the Indiana CTSI is to serve as the statewide catalyst for translational research and improve human health across Indiana, the nation and beyond. The Indiana CTSI fosters a collaborative research environment, provides resources and services to conduct the highest-quality clinical and translational research, offers education and training programs to build a robust translational workforce, engages our community as a partner at all levels, and functions as an exemplary member of the national CTSA network. The principle of continuous innovation cycle of ?4Ds?: Design, Demonstrate, Duplicate, and Disseminate guides the Indiana CTSI. The CTSI plans to accomplish its mission through five Specific Aims:
Aim I. Expand education and training to build a broader array of translational workforce through its Career development, Education and Research Training (CERT) and related suite of programs.
Aim II. Build on the robust Indiana translational research environment of collaboration and engagement with its outstanding Community Health Partnership (CHeP) program and its public-private partnerships throughout the state and beyond.
Aim III. Further, strengthen the CTSI?s integrated approach to support translational research across all phases and many scientific disciplines through its Project Development Teams (PDTs), and include a wide variety of populations across the lifespan.
Aim I V. Promote scientific approaches to design and implement the best methods and processes that accelerate the transit of ideas and health interventions across the translational stages to reach patients faster.
Aim V. Expand on the exceptional capabilities of the Indiana Translational Informatics Program (iTIP). During the next 5 years, the Indiana CTSI 3.0 will not only expand translational research across the state, but also address some of the major community health issues faced by Indiana and the nation. In this section, we first describe the transformative impact the Indiana CTSI has had on the local environment, and outline how it is poised to make greater impact locally and contribute to NCATS?s mission as an ideal Hub in the national CTSA network. Frequently used abbreviations: All IN ? All Indiana Health & Research; CERT ? Career development, Education and Research Training; CHeP ? Community Health Partnerships; CTR ? Clinical & Translational Research; EC ? Executive Council; iTIP ? Indiana Translational Informatics Program; IUB? Indiana University, Bloomington; IUPUI ? Indiana University?Purdue University Indianapolis; IU Health ? Indiana University Health hospitals; IUSM ? Indiana University School of Medicine; ND ? University of Notre Dame; PDT ? Project development team; PEC ? Patient Engagement Core; PU ? Purdue University; RKS ? Regulatory Knowledge and Support; SERVE ? Subject Engagement and Research Volunteer Enrollment. Project Summary/Abstract Page 704 Contact PD/PI: Shekhar, Anantha

Public Health Relevance

The Indiana CTSI 3.0 will not only expand translational research across the state, but also address some of the major community health issues faced by Indiana, and the nation. We will find novel approaches to integrating `precision medicine' and `population health', embrace the vision to train a new breed of research workforce skilled in team science and community engagement, and both deepen and expand the integration of research in our health systems. Project Narrative Page 705

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
1UL1TR002529-01
Application #
9623384
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Hsiao, H Timothy
Project Start
2018-05-18
Project End
2023-04-30
Budget Start
2018-05-18
Budget End
2019-04-30
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Takemura, Hiromasa; Pestilli, Franco; Weiner, Kevin S (2018) Comparative neuroanatomy: Integrating classic and modern methods to understand association fibers connecting dorsal and ventral visual cortex. Neurosci Res :
Filippelli, Gabriel M; Adamic, Jessica; Nichols, Deborah et al. (2018) Mapping the Urban Lead Exposome: A Detailed Analysis of Soil Metal Concentrations at the Household Scale Using Citizen Science. Int J Environ Res Public Health 15:
Ogbemudia, Blessing; Raymond, Jodi; Hatcher, LaRanna S et al. (2018) Assessing outpatient follow-up care compliance, complications, and sequelae in children hospitalized for isolated traumatic abdominal injuries. J Pediatr Surg :
Qiao, Nan; Carroll, Aaron E; Bell, Teresa Maria (2018) Factors affecting the Affordable Care Act Marketplace stand-alone pediatric dental plan premiums. J Public Health Dent 78:360-364
Feng, Shan; Cheng, Xi; Zhang, Lin et al. (2018) Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers. Proc Natl Acad Sci U S A 115:10094-10099
Alghnam, Suliman; Towhari, Jawaher; Alkelya, Mohamed et al. (2018) The effectiveness of introducing detection cameras on compliance with mobile phone and seatbelt laws: a before-after study among drivers in Riyadh, Saudi Arabia. Inj Epidemiol 5:31
Zhang, P; Du, L; Wang, L et al. (2015) A Mixture Dose-Response Model for Identifying High-Dimensional Drug Interaction Effects on Myopathy Using Electronic Medical Record Databases. CPT Pharmacometrics Syst Pharmacol 4:474-80
Hays, Travis R; Mund, Julie A; Liu, Ziyue et al. (2015) Brief report: Endothelial colony-forming cells and inflammatory monocytes in HIV. J Acquir Immune Defic Syndr 68:550-3
Akil, Ayman; Zhang, Qing; Mumaw, Christen L et al. (2015) Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant 21:1739-45
Nho, Kwangsik; Kim, Sungeun; Risacher, Shannon L et al. (2015) Protective variant for hippocampal atrophy identified by whole exome sequencing. Ann Neurol 77:547-52

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