The mission of the HIV Prevention Trials Network (HPTN) is to conduct research designed to identify the best combinations of HIV prevention interventions to prevent HIV infection in populations at the highest risk for this infection. The HPTN will be led by Drs. Wafaa EI-Sadr, Columbia University, and Myron S. Cohen, University of North Carolina at Chapel Hill, and supported by experienced operations, laboratory and statistical and data centers. The HPTN will address and support the two research Priority Areas in order to achieve the following eight Specific Aims:
Specific Aims for Priority Area 1: Integrate Strategies to Prevent HIV Infection:
Aim 1 : To develop an integrated strategy to prevent HIV infection in young women in Southern Africa;
Aim 2 : To develop integrated strategies to prevent HIV infection in men who have sex with men (MSM);Sub-aim 2a: To identify an integrated strategy to prevent HIV acquisition in HIV-uninfected MSM and transgender women in the Americas;Sub-aim 2b: To identify an integrated strategy to prevent HIV transmission from HIV-infected MSM in the United States (U.S.);
Aim 3 : To develop an integrated strategy to prevent HIV infection in injection drug users (IDUs) in Eastern Europe and Asia;
Aim 4 : To implement an integrated strategy to virtually eliminate (<1%) HIV transmission in discordant couples in sub-Saharan Africa {SSA};
Aim 5 : To develop methods to engage MSM in SSA in prevention research, paving the way for development of an integrated strategy to prevent HIV infection in this population Specific Aims for Priority Area 2: Pre-exposure Prophylaxis {PrEP}:
Aim 6 : To evaluate the efficacy of an ARV regimen containing maraviroc (MVC) for PrEP;
Aim 7 : To develop new agents for PrEP with favorable profiles, including long lasting agents;
Aim 8 : To develop pharmacostatistical models to define the role of new agents for PrEP.

Public Health Relevance

The research proposed by the HIV Prevention Trials Network (HPTN) aims to combine known interventions and identify new ones to stop the transmission of HIV infection with the goal of inspiring changes in public health policy and practice, and to ending the HIV epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
2UM1AI068619-08
Application #
8554608
Study Section
Special Emphasis Panel (ZAI1-TS-A (S1))
Program Officer
Gilbreath, Michael J
Project Start
2006-06-01
Project End
2020-11-30
Budget Start
2014-01-01
Budget End
2014-11-30
Support Year
8
Fiscal Year
2014
Total Cost
$7,636,556
Indirect Cost
$1,292,583
Name
Family Health International
Department
Type
DUNS #
067180786
City
Durham
State
NC
Country
United States
Zip Code
27713
El-Sadr, Wafaa M; Rabkin, Miriam; DeCock, Kevin M (2016) Population health and individualized care in the global AIDS response: synergy or conflict? AIDS 30:2145-8
Glidden, David V; Anderson, Peter L; Grant, Robert M (2016) Pharmacology supports on-demand PrEP. Lancet HIV 3:e405-6
Nelson, LaRon E; Wilton, Leo; Moineddin, Rahim et al. (2016) Economic, Legal, and Social Hardships Associated with HIV Risk among Black Men who have Sex with Men in Six US Cities. J Urban Health 93:170-88
Landovitz, Raphael J; Kofron, Ryan; McCauley, Marybeth (2016) The promise and pitfalls of long-acting injectable agents for HIV prevention. Curr Opin HIV AIDS 11:122-8
Glidden, David V; Amico, K Rivet; Liu, Albert Y et al. (2016) Symptoms, Side Effects and Adherence in the iPrEx Open-Label Extension. Clin Infect Dis 62:1172-7
Siskind, Rona L; Andrasik, Michele; Karuna, Shelly T et al. (2016) Engaging Transgender People in NIH-Funded HIV/AIDS Clinical Trials Research. J Acquir Immune Defic Syndr 72 Suppl 3:S243-7
Mayer, Kenneth H; Grinsztejn, Beatriz; El-Sadr, Wafaa M (2016) Transgender People and HIV Prevention: What We Know and What We Need to Know, a Call to Action. J Acquir Immune Defic Syndr 72 Suppl 3:S207-9
Safren, Steven A; Hughes, James P; Mimiaga, Matthew J et al. (2016) Frequency and predictors of estimated HIV transmissions and bacterial STI acquisition among HIV-positive patients in HIV care across three continents. J Int AIDS Soc 19:21096
Schackman, Bruce R; Eggman, Ashley A; Leff, Jared A et al. (2016) Costs of Expanded Rapid HIV Testing in Four Emergency Departments. Public Health Rep 131 Suppl 1:71-81
Pettifor, Audrey; MacPhail, Catherine; Selin, Amanda et al. (2016) HPTN 068: A Randomized Control Trial of a Conditional Cash Transfer to Reduce HIV Infection in Young Women in South Africa-Study Design and Baseline Results. AIDS Behav 20:1863-82

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