The mission of the HIV Prevention Trials Network (HPTN) is to conduct research designed to identify the best combinations of HIV prevention interventions to prevent HIV infection in populations at the highest risk for this infection. The HPTN will be led by Drs. Wafaa EI-Sadr, Columbia University, and Myron S. Cohen, University of North Carolina at Chapel Hill, and supported by experienced operations, laboratory and statistical and data centers. The HPTN will address and support the two research Priority Areas in order to achieve the following eight Specific Aims:
Specific Aims for Priority Area 1: Integrate Strategies to Prevent HIV Infection:
Aim 1 : To develop an integrated strategy to prevent HIV infection in young women in Southern Africa;
Aim 2 : To develop integrated strategies to prevent HIV infection in men who have sex with men (MSM); Sub-aim 2a: To identify an integrated strategy to prevent HIV acquisition in HIV-uninfected MSM and transgender women in the Americas; Sub-aim 2b: To identify an integrated strategy to prevent HIV transmission from HIV-infected MSM in the United States (U.S.);
Aim 3 : To develop an integrated strategy to prevent HIV infection in injection drug users (IDUs) in Eastern Europe and Asia;
Aim 4 : To implement an integrated strategy to virtually eliminate (<1%) HIV transmission in discordant couples in sub-Saharan Africa {SSA};
Aim 5 : To develop methods to engage MSM in SSA in prevention research, paving the way for development of an integrated strategy to prevent HIV infection in this population Specific Aims for Priority Area 2: Pre-exposure Prophylaxis {PrEP}:
Aim 6 : To evaluate the efficacy of an ARV regimen containing maraviroc (MVC) for PrEP;
Aim 7 : To develop new agents for PrEP with favorable profiles, including long lasting agents;
Aim 8 : To develop pharmacostatistical models to define the role of new agents for PrEP.

Public Health Relevance

The research proposed by the HIV Prevention Trials Network (HPTN) aims to combine known interventions and identify new ones to stop the transmission of HIV infection with the goal of inspiring changes in public health policy and practice, and to ending the HIV epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1AI068619-09
Application #
8782598
Study Section
Special Emphasis Panel ()
Program Officer
Gilbreath, Michael J
Project Start
2006-06-01
Project End
2020-11-30
Budget Start
2014-12-01
Budget End
2015-11-30
Support Year
9
Fiscal Year
2015
Total Cost
$20,980,154
Indirect Cost
$2,174,398
Name
Family Health International
Department
Type
DUNS #
067180786
City
Durham
State
NC
Country
United States
Zip Code
27701
Sivay, Mariya V; Li, Maoji; Piwowar-Manning, Estelle et al. (2017) Characterization of HIV Seroconverters in a TDF/FTC PrEP Study: HPTN 067/ADAPT. J Acquir Immune Defic Syndr 75:271-279
Latkin, Carl A; Van Tieu, Hong; Fields, Sheldon et al. (2017) Social Network Factors as Correlates and Predictors of High Depressive Symptoms Among Black Men Who Have Sex with Men in HPTN 061. AIDS Behav 21:1163-1170
Fogel, Jessica M; Piwowar-Manning, Estelle; Debevec, Barbara et al. (2017) Brief Report: Impact of Early Antiretroviral Therapy on the Performance of HIV Rapid Tests and HIV Incidence Assays. J Acquir Immune Defic Syndr 75:426-430
Cordes, Jillian L; Stangl, Anne; Krishnaratne, Shari et al. (2017) Trends in Responses to DHS Questions Should Not Be Interpreted as Reflecting an Increase in ""Anticipated Stigma"" in Africa. J Acquir Immune Defic Syndr 75:e22-e23
Gulick, Roy M; Wilkin, Timothy J; Chen, Ying Q et al. (2017) Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women: A Phase 2 Randomized Trial. Ann Intern Med 167:384-393
Salazar-Austin, N; Kulich, M; Chingono, A et al. (2017) Age-Related Differences in Socio-demographic and Behavioral Determinants of HIV Testing and Counseling in HPTN 043/NIMH Project Accept. AIDS Behav :
Palumbo, Philip J; Fogel, Jessica M; Hudelson, Sarah E et al. (2017) Hiv Drug Resistance in Adults Receiving Early Versus Delayed Antiretroviral Therapy: Hptn 052. J Acquir Immune Defic Syndr :
Stoner, Marie C D; Edwards, Jessie K; Miller, William C et al. (2017) Effect of Schooling on Age-Disparate Relationships and Number of Sexual Partners Among Young Women in Rural South Africa Enrolled in HPTN 068. J Acquir Immune Defic Syndr 76:e107-e114
Zhang, Yinfeng; Clarke, William; Marzinke, Mark A et al. (2017) Evaluation of a Multidrug Assay for Monitoring Adherence to a Regimen for HIV Preexposure Prophylaxis in a Clinical Study, HIV Prevention Trials Network 073. Antimicrob Agents Chemother 61:
Eshleman, Susan H; Wilson, Ethan A; Zhang, Xinyi C et al. (2017) Virologic outcomes in early antiretroviral treatment: HPTN 052. HIV Clin Trials 18:100-109

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