: The Oswaldo Cruz Foundation (FIOCRUZ) Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials), is a multidisciplinary, integrated research center based in Rio de Janeiro, Brazil that is partnered with the Institute de Pesquisa Clinica Evandro Chagas Clinical Research Site (IPEC CRS), Together the FioTrials CTU and IPEC CRS provide care for both at-risk and HIV infected persons and cater to the needs of certain disenfranchised populations, including men who have sex with men (MSM), transgender women, racial minorities, women, and those who are poverty stricken and/or uneducated. The FioTrials CTU and IPEC CRS have unique strengths to offer the AIDS Clinical Trials Group (ACTG), HIV Prevention Trials Network (HPTN) and Microbicide Trials Network (MTN), including a cadre of leading researchers; a partnership with FIOCRUZ, an internationally-recognized governmental organization dedicated to public health research; and a participant population that compliments the scientific agendas of each network. The goal of our research is to 1) evaluate and implement integrated strategies (therapeutic and behavioral) to prevent HIV acquisition in MSM, transgender women and women; 2) evaluate the safety, efficacy and utility of rectal microbicides for our MSM population; 3) evaluate novel diagnostics, technologies, prevention and treatment interventions for tuberculosis in HIV co-infected individuals; 4) evaluate novel treatment strategies for hepatitis C, particularly for those with HI co-infection; and 5) assess novel therapeutics and improve existing HIV treatment strategies and prevent co-morbidities. Achievement of these objectives will be attributed to the outstanding infrastructure of the FioTrials CTU, its CRS and its community-focused research strategies.

Public Health Relevance

The FioTrials CTU will continue to make significant contributions to the fight against the HIV/AIDS and tuberculosis epidemics in Brazil and throughout Latin America, particularly for the population of MSM and transgender women who are the most heavily affected by the burden of HIV in Brazil.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1AI069476-08
Application #
8784166
Study Section
Special Emphasis Panel (ZAI1-DR-A (S2))
Program Officer
Tauscher, Gail H
Project Start
2008-01-15
Project End
2020-11-30
Budget Start
2014-12-01
Budget End
2015-11-30
Support Year
8
Fiscal Year
2015
Total Cost
$1
Indirect Cost
$49,690
Name
Fundacao Oswaldo Cruz
Department
Type
DUNS #
899294177
City
Rio de Janeiro
State
Country
Brazil
Zip Code
21040--360
de Azevedo, Suwellen S D; Caetano, Diogo Gama; Côrtes, Fernanda H et al. (2017) Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers. Retrovirology 14:29
Machado, Iona K; Luz, Paula M; Lake, Jordan E et al. (2017) Self-rated health and substance use among individuals in HIV care in Rio de Janeiro, Brazil: a cross-sectional study. Int J STD AIDS 28:1175-1183
Badal-Faesen, Sharlaa; Firnhaber, Cynthia; Kendall, Michelle A et al. (2017) Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis. J Clin Med 6:
Coelho, Lara E; Ribeiro, Sayonara R; Japiassu, Andre M et al. (2017) Thirty-day Readmission Rates in an HIV-infected Cohort From Rio de Janeiro, Brazil. J Acquir Immune Defic Syndr 75:e90-e98
Caniglia, Ellen C; Cain, Lauren E; Sabin, Caroline A et al. (2017) Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study. Lancet HIV 4:e251-e259
da Silva Escada, Rodrigo Otavio; Velasque, Luciane; Ribeiro, Sayonara Rocha et al. (2017) Mortality in patients with HIV-1 and tuberculosis co-infection in Rio de Janeiro, Brazil - associated factors and causes of death. BMC Infect Dis 17:373
Perazzo, Hugo; Pacheco, Antonio G; Luz, Paula M et al. (2017) Age-standardized mortality rates related to viral hepatitis in Brazil. BMC Infect Dis 17:527
Truong, Hong-Ha M; Mehrotra, Megha; Montoya, Orlando et al. (2017) International Sexual Partnerships May Be Shaped by Sexual Histories and Socioeconomic Status. Sex Transm Dis 44:306-309
Couto, Ingrid; Victoria, Marilu; Veloso, Valdiléa G et al. (2017) Prevalence and predictors for compensated Advanced Chronic Liver Disease (c-ACLD) in patients with chronic Hepatitis Delta Virus (HDV) infection. PLoS One 12:e0174453
Tenforde, Mark W; Yadav, Ashish; Dowdy, David W et al. (2017) Vitamin A and D Deficiencies Associated With Incident Tuberculosis in HIV-Infected Patients Initiating Antiretroviral Therapy in Multinational Case-Cohort Study. J Acquir Immune Defic Syndr 75:e71-e79

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