The CHAVI-ID will be established as an integrated, priority-setting consortium with major components at multiple participating institutions and substantial NIH programmatic involvement in a collaborative partnership role with the Awardee to advance the science. Therefore, the Operations and Management Scientific Research Support Component (SRSC) is designed to function across institutional and geographic boundaries to provide the administrative activities that allow successful scientific collaboration and flow of resources. For efficiency of operations, the overall administrative and scientific management will be centralized, with the Operations and Management SRSC based at The Scripps Research Institute (TSRI), the Sponsoring Institution. The SRSC will be overseen by the CHAVI-ID Director and an on-site experienced Chief Operating Officer will dedicate 100% effort to managing CHAVI-ID administrative activities. An Operations Team will function on the premise of flexibility, as evolving scientific priorities and collaborative demands are to be expected during the extended period of the award. However, the flexibility will not be at the expense of efficiency or responsiveness to the needs of the collaborating scientific institutions. This management structure will effectively leverage the associated resources and program offices offered by TSRI.
The Specific Aims of the SRSC are:
Aim 1 : To establish a highly efficient operations and management structure that will provide essential support services to all CHAVI-ID investigators and leverage available resources at the sponsoring and collaborating institutions Aim 2: To assist the flow of information and scientific collaboration between CHAVI-ID Focus Teams by supporting meeting, teleconference, and information technology demands Aim 3: To implement the decisions of the CHAVI-ID Director and Leadership regarding direction of the Strategic Plan, allocation of future funding support, and changing composition of the group of collaborating CHAVI-ID scientists

Public Health Relevance

This SRSC offers efficient management of all CHAVI-ID operational issues to support successful scientific collaboration thereby advancing the Strategic Plan. A decision-making structure is established to ensure that the CHAVI-ID can respond to changing priorities as scientific discoveries are made and implement strategies to advance all phases of immunogen development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1AI100663-02
Application #
8508852
Study Section
Special Emphasis Panel (ZAI1-JBS-A)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$850,215
Indirect Cost
$343,715
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Rantalainen, Kimmo; Berndsen, Zachary T; Murrell, Sasha et al. (2018) Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design. Cell Rep 23:3249-3261
Bar-On, Yotam; Gruell, Henning; Schoofs, Till et al. (2018) Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals. Nat Med 24:1701-1707
Watanabe, Yasunori; Raghwani, Jayna; Allen, Joel D et al. (2018) Structure of the Lassa virus glycan shield provides a model for immunological resistance. Proc Natl Acad Sci U S A 115:7320-7325
Allen, Joel D; Sanders, Rogier W; Doores, Katie J et al. (2018) Harnessing post-translational modifications for next-generation HIV immunogens. Biochem Soc Trans 46:691-698
Gautam, Rajeev; Nishimura, Yoshiaki; Gaughan, Natalie et al. (2018) A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection. Nat Med 24:610-616
Young, Gavin; Hundt, Nikolas; Cole, Daniel et al. (2018) Quantitative mass imaging of single biological macromolecules. Science 360:423-427
Dosenovic, Pia; Kara, Ervin E; Pettersson, Anna-Klara et al. (2018) Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity. Proc Natl Acad Sci U S A 115:4743-4748
Richard, Jonathan; Prévost, Jérémie; Baxter, Amy E et al. (2018) Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses. MBio 9:
Abbott, Robert K; Lee, Jeong Hyun; Menis, Sergey et al. (2018) Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens. Immunity 48:133-146.e6
Pauthner, Matthias G; Nkolola, Joseph P; Havenar-Daughton, Colin et al. (2018) Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers. Immunity :

Showing the most recent 10 out of 336 publications