The Data Management (DM) Scientific Research Support Component (SRSC) aims to support the CHAVI-ID by providing comprehensive data management for the entire Center and to provide biostatistics and data analysis support for Center members. Specifically, the DM SRSC will provide archiving for all the data collected in the CHAVI-ID and develop a central database that will allow members and other approved collaborators to access, search and analyze the data. This SRSC will provide leadership and technical expertise to ensure consistency and quality control in data collection, collect all information on experimental protocols, procedures, sample acquisition and distribution. The SRSC will also provide support for data collection and analysis in the Center and provide access to the data generated by the CHAVI-ID to the broad scientific community. These goals will be accomplished by: 1. Establishing a backend data collection and archival infrastructure that will provide the essential backbone for data exchange between all CHAVI-ID components and investigators 2. Establishing a frontend multifaceted data management system, integrating data collected from all CHAVI-ID components into a unified database to facilitate data mining and analysis. 3. Establishing infrastructure to provide controlled access to the data collected in the project, for download and for searching and analysis, both to the Center members and to the broad scientific community. 4. Developing a central website that will serve as the main gateway to the CHAVI-ID, where outside users could access information about the project and data generated within the project, but also provide input send requests and submit proposals

Public Health Relevance

This Data Management SRSC supports the CHAVI-ID by providing centralized data management, including data archiving, searches and analyses of the collected data. This is critical for both for functioning of the Center and for providing access to its results to the broad scientific community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1AI100663-03
Application #
8681354
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Scheid, Johannes F; Horwitz, Joshua A; Bar-On, Yotam et al. (2016) HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 535:556-60
Barton, John P; Goonetilleke, Nilu; Butler, Thomas C et al. (2016) Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable. Nat Commun 7:11660
Briney, Bryan; Sok, Devin; Jardine, Joseph G et al. (2016) Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies. Cell 166:1459-1470.e11
Landais, Elise; Huang, Xiayu; Havenar-Daughton, Colin et al. (2016) Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort. PLoS Pathog 12:e1005369
van Gils, Marit J; van den Kerkhof, Tom L G M; Ozorowski, Gabriel et al. (2016) An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability. Nat Microbiol 2:16199
Moldt, Brian; Le, Khoa; Carnathan, Diane G et al. (2016) Neutralizing antibody affords comparable protection against vaginal and rectal SHIV challenge in macaques. AIDS :
Lu, Ching-Lan; Murakowski, Dariusz K; Bournazos, Stylianos et al. (2016) Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo. Science 352:1001-4
Tam, Hok Hei; Melo, Mariane B; Kang, Myungsun et al. (2016) Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. Proc Natl Acad Sci U S A 113:E6639-E6648
Havenar-Daughton, Colin; Carnathan, Diane G; Torrents de la Peña, Alba et al. (2016) Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer. Cell Rep 17:2195-2209
Dan, Jennifer M; Lindestam Arlehamn, Cecilia S; Weiskopf, Daniela et al. (2016) A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood. J Immunol 197:983-93

Showing the most recent 10 out of 206 publications