This application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California between 1993 and 1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the senior investigators in nutrition, ethnic/racial studies, and, subsequently, genetics. It is the most ethnically heterogeneous cancer cohort in existence. At baseline, the cohort included information on 215,000 men and women, comprised, by design, almost entirely of five ethnic/racial populations: Caucasians, Japanese Americans, Native Hawaiians, African Americans, and Latinos. The resource was later expanded to include a prospective bio repository of blood and urine specimens from ~ 70,000 of the participants. Leadership of the MEC entails a highly interactive, team approach;and the investigators have amply demonstrated their willingness to share data and participate actively in consortium projects. This application describes our aims over the next five years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research in the areas of genetic and nutritional epidemiology that utilize the resources of the cohort. Research accomplishments to date include significant contributions to understanding both genetic and environmental risk factors for cancer, particularly related to breast, prostate, colorectal and lun cancers. Nearly 250 papers describing these findings have been published. In addition, primarily over the last 20 years, more than 50 research grants have been built around the MEC, and more than 50 students and postdoctoral fellows have been trained on the study. This new grant will make possible the continuation of a well-integrated program of research aimed at evaluating environmental factors and genetic variants as risk factors for cancer and other common chronic diseases.

Public Health Relevance

The Multiethnic Cohort Study is a powerful resource for continuing research efforts aimed at greater understanding ofthe environmental causes of cancer and other chronic diseases, and how these risk factors interact with genetic variants to explain some of the ethnic/racial disparities in cancer risks in the U,S. population. It is our hope that this work ultimately will provide useful insights into the prevention, early detection and treatment of cancer

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project with Complex Structure Cooperative Agreement (UM1)
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Special Emphasis Panel (ZCA1)
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Mahabir, Somdat
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University of Hawaii
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Leo, Q J N; Ollberding, N J; Wilkens, L R et al. (2016) Nutritional factors and non-Hodgkin lymphoma survival in an ethnically diverse population: the Multiethnic Cohort. Eur J Clin Nutr 70:41-6
Park, Sungshim L; Tiirikainen, Maarit I; Patel, Yesha M et al. (2016) Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity. Carcinogenesis 37:269-79
Maskarinec, G; Morimoto, Y; Jacobs, S et al. (2016) Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort. Eur J Clin Nutr 70:1022-7
Setiawan, Veronica Wendy; Stram, Daniel O; Porcel, Jacqueline et al. (2016) Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: The multiethnic cohort. Hepatology 64:1969-1977
Vigen, Cheryl; Kwan, Marilyn L; John, Esther M et al. (2016) Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC). Cancer Causes Control 27:391-401
Setiawan, V Wendy; Wei, Pengxiao C; Hernandez, Brenda Y et al. (2016) Reply to high hepatocellular carcinoma risk among US-born Hispanics. Cancer :
Sposto, Richard; Keegan, Theresa H M; Vigen, Cheryl et al. (2016) The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality. Cancer Epidemiol Biomarkers Prev 25:1064-72
Zanetti, Krista A; Wang, Zhaoming; Aldrich, Melinda et al. (2016) Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer 98:33-42
Setiawan, Veronica Wendy; Pandol, Stephen J; Porcel, Jacqueline et al. (2016) Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort. Pancreas 45:819-25
Ruiz-Narváez, Edward A; Lunetta, Kathryn L; Hong, Chi-Chen et al. (2016) Genetic variation in the insulin, insulin-like growth factor, growth hormone, and leptin pathways in relation to breast cancer in African-American women: the AMBER consortium. NPJ Breast Cancer 2:

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