We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project;consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive;341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer;strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer;and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.

Public Health Relevance

The goal of this proposal is to continue the follow-up of HPFS, the only large cohort of men with biomarkers and repeated measures of diet, physical activity, and other exposures over several decades, now in a maximally informative phase and is a unique resource for scientific aims that integrate diet and other environmental variables, biomarkers, genetic predisposition and mediating variables in relation to cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project with Complex Structure Cooperative Agreement (UM1)
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Special Emphasis Panel (ZCA1-SRLB-3 (J1))
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Mahabir, Somdat
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Harvard University
Schools of Public Health
United States
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Mekary, Rania A; Grøntved, Anders; Despres, Jean-Pierre et al. (2015) Weight training, aerobic physical activities, and long-term waist circumference change in men. Obesity (Silver Spring) 23:461-7
Zhang, Ran; Chomistek, Andrea K; Dimitrakoff, Jordan D et al. (2015) Physical activity and chronic prostatitis/chronic pelvic pain syndrome. Med Sci Sports Exerc 47:757-64
Ananthakrishnan, Ashwin N; Du, Mengmeng; Berndt, Sonja I et al. (2015) Red meat intake, NAT2, and risk of colorectal cancer: a pooled analysis of 11 studies. Cancer Epidemiol Biomarkers Prev 24:198-205
Alemozaffar, Mehrdad; Sanda, Martin; Yecies, Derek et al. (2015) Benchmarks for operative outcomes of robotic and open radical prostatectomy: results from the Health Professionals Follow-up Study. Eur Urol 67:432-8
Song, Mingyang; Gong, Jian; Giovannucci, Edward L et al. (2015) Genetic variants of adiponectin and risk of colorectal cancer. Int J Cancer 137:154-64
Inamura, Kentaro; Yamauchi, Mai; Nishihara, Reiko et al. (2015) Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma. Ann Surg Oncol 22:1226-35
Kang, Jae H; Wiggs, Janey L; Pasquale, Louis R (2014) Relation between time spent outdoors and exfoliation glaucoma or exfoliation glaucoma suspect. Am J Ophthalmol 158:605-14.e1
Inamura, Kentaro; Yamauchi, Mai; Nishihara, Reiko et al. (2014) Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis. J Natl Cancer Inst 106:
Yoo, Sun; Pettersson, Andreas; Jordahl, Kristina M et al. (2014) Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer. Cancer Epidemiol Biomarkers Prev 23:2027-31
Jung, Seungyoun; Qian, Zhi Rong; Yamauchi, Mai et al. (2014) Predicted 25(OH)D score and colorectal cancer risk according to vitamin D receptor expression. Cancer Epidemiol Biomarkers Prev 23:1628-37

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