The Shanghai Men's Health Study (SMHS), funded by NCI since 2001 (R0I CA082729), is a population based cohort study of 61,491 men who were recruited between 2002 and 2006 and have been followed through multiple in-person follow-up surveys and record linkages. Over the years, data and biological samples collected in the SMHS have been used to evaluate many important etiologic hypotheses and support multiple studies, including over 25 consortium projects. To both sustain and expand its resources and success, we are applying for infrastructure funding with the following specific aims: 1) Continue the follow-up of this cohort for cancer incidence and cause-specific mortality and expand the cohort's resources by conducting in-person interviews to update information on exposures and selected disease outcomes;2) Maintain the data bank and biorepository of the SMHS and implement quality control protocols to maximize the value of its resources for scientific research;3) Collect blood and urine samples from 6,000 study participants to enhance our ability to study intermediate disease biomarkers as a consequence of exposures assessed at the baseline and subsequent follow-ups;4) Collect information related to the diagnosis and treatment of common chronic diseases for cohort members by searching the database of an electronic Health Information System covering the study population;5) Collect tumor tissue samples and detailed information on cancer treatment, recurrence, and survivorship for participants diagnosed with cancers of the lung, stomach, colon/rectum, liver, and prostate, the five most common cancers in the cohort, as well as collect post-diagnosis lifestyle factor and quality of life information for survivors of stomach, colon/rectum, and prostate cancer;6).To build a website to promote and facilitate collaborations among the broader community of cancer researchers, to disseminate research findings, and to attract and cultivate new investigators. The SMHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in any other existing cohort study. Continuing follow-up of the cohort and expansion of its resources would further increase the value of the SMHS for a long-term epidemiologic study of cancer and other chronic diseases.

Public Health Relevance

The Shanghai Men's Health Study (SMHS) is a population-based cohort study of 61,491 men who were recruited between 2002 and 2006 and have been followed for cancer incidence and cause-specific mortality following rigorous study protocols. Over the years, data and biological samples collected in this study have been used to evaluate many important etiologic hypotheses and support multiple other research projects. Continued follow-up of this unique cohort and expanding its resources will provide an exceptional opportunity to address many significant hypotheses that cannot be adequately investigated in any other existing cohort studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
1UM1CA173640-01A1
Application #
8580649
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (M2))
Program Officer
Mahabir, Somdat
Project Start
2013-09-18
Project End
2018-08-31
Budget Start
2013-09-18
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$970,385
Indirect Cost
$212,418
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Kitahara, Cari M; McCullough, Marjorie L; Franceschi, Silvia et al. (2016) Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies. Thyroid 26:306-18
Xiao, Qian; Moore, Steven C; Keadle, Sarah K et al. (2016) Objectively measured physical activity and plasma metabolomics in the Shanghai Physical Activity Study. Int J Epidemiol :
Sun, Jiang-Wei; Shu, Xiao-Ou; Li, Hong-Lan et al. (2016) Dietary selenium intake and mortality in two population-based cohort studies of 133 957 Chinese men and women. Public Health Nutr 19:2991-2998
Zeng, Chenjie; Matsuda, Koichi; Jia, Wei-Hua et al. (2016) Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Gastroenterology 150:1633-45
Yang, Yang; Gao, Jing; Li, Hong-Lan et al. (2016) Dose-response association between hepatitis B surface antigen levels and liver cancer risk in Chinese men and women. Int J Cancer 139:355-62
Wen, Wanqing; Kato, Norihiro; Hwang, Joo-Yeon et al. (2016) Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep 6:17958
Cai, Hui; Ye, Fei; Michel, Angelika et al. (2016) Helicobacter pylori blood biomarker for gastric cancer risk in East Asia. Int J Epidemiol 45:774-81
Ren, H G; Luu, H N; Cai, H et al. (2016) Oral health and risk of colorectal cancer: results from three cohort studies and a meta-analysis. Ann Oncol 27:1329-36
Yu, Danxia; Moore, Steven C; Matthews, Charles E et al. (2016) Plasma metabolomic profiles in association with type 2 diabetes risk and prevalence in Chinese adults. Metabolomics 12:
Yang, Wan-Shui; Li, Hong-Lan; Xu, Hong-Li et al. (2016) Type 2 diabetes and the risk of non-Hodgkin's lymphoma: a report from two population-based cohort studies in China. Eur J Cancer Prev 25:149-54

Showing the most recent 10 out of 69 publications