The Shanghai Women's Health Study (SWHS, R37 CA070867) is a population-based cohort study of approximately 75,000 Chinese women who were recruited between 1997 and 2000 and have been followed via multiple in-person surveys and record linkages with population-based registries. Over the years, data and biological samples collected in the SWMS have been used to evaluate many important etiologic hypotheses and support multiple studies, including about 40 research consortia. To sustain and expand SWHS resources and success, we are applying for infrastructure funding.
Specific aims : 1) Continue cohort follow-up for cancer incidence and cause-specific mortality and conduct additional in-person interviews to obtain information regarding exposures and selected disease outcomes;2) Maintain SWHS data bank and biorepository to support research and facilitate data sharing with the scientific community;3) Collect and store stool samples from approximately 40,000 living cohort members for future research of fecal microbiota and other biomarkers;4) Establish resources for clinical and pharmaco-epidemiologic research through linkage with population-based electronic medical databases;5) Continue to collect tumor tissue samples among cohort members diagnosed with cancer to study tumor markers. The SWHS, with its large sample size, wealth of resources, and unique exposure patterns and disease spectrum, provides exceptional opportunities to address many significant hypotheses that cannot be adequately investigated in other existing cohorts. Results from the SWHS will have significant impact on reducing the incidence and mortality of cancer and other noncommunicable diseases, the major causes of death in most countries.

Public Health Relevance

The Shanghai Women's Health Study is a population-based cohort study of approximately 75,000 women who were recruited between 1997 and 2000. This cohort study will provide exceptional opportunities to investigate many highly significant issues related to the etiology, genetics, and prevention of cancer and noncommunicable diseases.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project with Complex Structure Cooperative Agreement (UM1)
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Special Emphasis Panel (ZCA1-SRLB-9 (O2))
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Mahabir, Somdat
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Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
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Yu, Danxia; Moore, Steven C; Matthews, Charles E et al. (2016) Plasma metabolomic profiles in association with type 2 diabetes risk and prevalence in Chinese adults. Metabolomics 12:
Yang, Wan-Shui; Li, Hong-Lan; Xu, Hong-Li et al. (2016) Type 2 diabetes and the risk of non-Hodgkin's lymphoma: a report from two population-based cohort studies in China. Eur J Cancer Prev 25:149-54
Liao, Linda M; Friesen, Melissa C; Xiang, Yong-Bing et al. (2016) Occupational Lead Exposure and Associations with Selected Cancers: The Shanghai Men's and Women's Health Study Cohorts. Environ Health Perspect 124:97-103
Imamura, Minako; Takahashi, Atsushi; Yamauchi, Toshimasa et al. (2016) Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun 7:10531
Kim, Christopher; Seow, Wei Jie; Shu, Xiao-Ou et al. (2016) Cooking Coal Use and All-Cause and Cause-Specific Mortality in a Prospective Cohort Study of Women in Shanghai, China. Environ Health Perspect 124:1384-9
Baglia, Michelle L; Zheng, Wei; Li, Honglan et al. (2016) The association of soy food consumption with the risk of subtype of breast cancers defined by hormone receptor and HER2 status. Int J Cancer 139:742-8
Kitahara, Cari M; McCullough, Marjorie L; Franceschi, Silvia et al. (2016) Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies. Thyroid 26:306-18
Xiao, Qian; Moore, Steven C; Keadle, Sarah K et al. (2016) Objectively measured physical activity and plasma metabolomics in the Shanghai Physical Activity Study. Int J Epidemiol :
Sun, Jiang-Wei; Shu, Xiao-Ou; Li, Hong-Lan et al. (2016) Dietary selenium intake and mortality in two population-based cohort studies of 133 957 Chinese men and women. Public Health Nutr 19:2991-2998
Zeng, Chenjie; Matsuda, Koichi; Jia, Wei-Hua et al. (2016) Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. Gastroenterology 150:1633-45

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