Bariatric surgery is effective in treating extreme obesity in adults, and is most commonly used in the 5th decade of life. However, as the prevalence of extreme obesity in adolescence increases, more and more youth are seeking bariatric surgery. Many questions regarding the health benefits and risks of surgical weight loss in adolescents still remain. In 2006, Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) was awarded funds as an ancillary study to Longitudinal Assessment of Bariatric Surgery (LABS). The TeenLABS central hypothesis was that severe obesity in adolescence is associated with medical and psychosocial impairments which may be more effectively treated with bariatric surgery during adolescence rather than later in adulthood. During the initial 5 years of Teen-LABS, several noteworthy achievements were accomplished: establishment of a research infrastructure, including several sub-committees and work groups;enrollment of 207 subjects (through January 2011) - over 80% of the desired 250 subjects; infrastructure supporting 10 ancillary studies and 3 sub-studies;and collection and storage of biospecimens (DNA, serum, plasma, urine) in the NIDDK-Biospecimen Repository. The Data Coordinating Center (DCC) thus far has established a research infrastructure and database characterized by standardized and rigorous data collection, data accuracy, and completeness. The overarching goals ofthe Teen LABS study forthe five year renewal period will focus on the completion of stated goals ofthe Teen LABS protocol, in addition to several other new areas of scientific investigation. With this extension, the core functions of DCC will be to continue support of Consortium processes and investigators by focusing on core responsibilities including: data collection and management, statistical analysis and reporting, laboratory and repository sample tracking, partnership in study publications, coordination of study meetings, study staff training &certification. IRB and NIH reporting requirements, site auditing and monitoring, database quality assurance, coordination and support of all study committee functions, DSMB and Steering Committee meeting coordination, and informed consent tracking.

Public Health Relevance

There is little evidence to suggest non-surgical treatments of obesity are effective in youth. However, the safety and efficacy of bariatric surgery in adolescents has not yet been established. Extending Teen-LABS DCC funding for five additional years will take advantage of a well-developed research infrastructure that enables the consortium to address scientifically important research questions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
3UM1DK095710-04S1
Application #
8920687
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (O1))
Program Officer
Horlick, Mary
Project Start
2011-09-23
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
$339,536
Indirect Cost
$62,517
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Xiao, Nianzhou; Jenkins, Todd M; Nehus, Edward et al. (2014) Kidney function in severely obese adolescents undergoing bariatric surgery. Obesity (Silver Spring) 22:2319-25
Michalsky, Marc P; Inge, Thomas H; Teich, Steven et al. (2014) Adolescent bariatric surgery program characteristics: the Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study experience. Semin Pediatr Surg 23:5-10
Inge, Thomas H; Zeller, Meg H; Jenkins, Todd M et al. (2014) Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr 168:47-53
Chuang, Janet; Zeller, Meg H; Inge, Thomas et al. (2013) Bariatric surgery for severe obesity in two adolescents with type 1 diabetes. Pediatrics 132:e1031-4