Cancer is the second leading cause of death in the United States after heart disease[1], anticipated to cause 570,000 deaths in 2012 alone. The most common cancers in the United States are lung, skin, breast, prostate, and colon cancer[2]. There have been tremendous advances in pre-clinical and clinical development of molecularly targeted therapies for these common cancers such as inhibitors of the epidermal growth factor receptor (EGFR), BRAF kinase, ERBB2 gene amplification (HER2), and androgen signaling pathway5(3-5]. In contrast to common cancers, rare cancers such as sarcomas present a challenge to the clinical oncologist since there are typically few retrospective studies available and little known about the molecular underpinnings. Thus, this clinical tumor sequencing study focuses on patients with these rare cancers to 1) provide clinically significant genomic sequencing data to patients and their doctors, and 2) expand the molecular taxonomy of these poorly defined cancers.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1HG006508-02
Application #
8703740
Study Section
Special Emphasis Panel (ZHG1-HGR-N)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$394,551
Indirect Cost
$140,753
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Mehra, Rohit; Vats, Pankaj; Kalyana-Sundaram, Shanker et al. (2014) Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. Am J Pathol 184:584-91
McDaniel, Andrew S; Zhai, Yali; Cho, Kathleen R et al. (2014) HRAS mutations are frequent in inverted urothelial neoplasms. Hum Pathol 45:1957-65
Roberts, J Scott; Dolinoy, Dana C; Tarini, Beth A (2014) Emerging issues in public health genomics. Annu Rev Genomics Hum Genet 15:461-80