The mechanisms by which the genotype influences the neuropharmacological and behavioral effects of alcohol use remain only poorly understood. These investigations explore the relationships between genotype and the neuropharmacological and behavioral effects of ethanol in a series of inbred strains of mice. These investigations concentrate (although not exclusively) on serotonergic, adrenergic and GABAergic systems since these have been strongly implicated in the neuropharmacological effects of ethanol. Differences in levels of neurotransmitters, their metabolites and the metabolizing enzymes are assessed by radioligand binding techniques. Genetic variation in behavior is asses using established tests of locomotion, exploration, anxiety and aggression. A greater understanding of these relationships lead to fuller appreciation of the mechanisms by which genes influence alcohol-related behaviors.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000074-01
Application #
3789515
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code