The focus of this laboratory has been the MHC class I molecule, classically considered a molecular heterodimer consisting of a 46 kd polymorphic heavy chain, exemplified by the murine H-2K, D, and L molecules (analogous to the human HLA-A, -B, and -C molecules), that is non-covalently assembled with the 12 kd monomorphic light chain, beta2-microglobulin. Our objectives in this project have been to develop an in vitro system for examining early events in the folding and assembly of the MHC molecules.
| Natarajan, K; Li, H; Mariuzza, R A et al. (1999) MHC class I molecules, structure and function. Rev Immunogenet 1:32-46 |
| Plaksin, D; Chacko, S; Navaza, J et al. (1999) The X-ray crystal structure of a Valpha2.6Jalpha38 mouse T cell receptor domain at 2.5 A resolution: alternate modes of dimerization and crystal packing. J Mol Biol 289:1153-61 |
