Natural Killer (NK) cells have been previously reported to both activate and inhibit B cell functions. This regulation is not well understood and depends both on the activation state of the NK cell and/or the B cell. In order to better understand this regulation, a binding methodology has been established between the NK and B cell where limited interaction occurs and the cells are then separated by physical shear and magnetic bead depletion. Using this novel procedure, the mechanism of Ig regulation by NK cells is under study.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC009256-18
Application #
6433140
Study Section
(LEI)
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code