Recent reports describe avascular necrosis of the hip in patients with human immunodeficiency virus infection. This incidence, natural history, and cause are not understood. In this study, patients with no hip complaints will be offered magnetic resonance imaging of the hips. This will allow calculation of the prevalence of this abnormality. Predisposing causes will be sought. The natural history of radiologic lesions will be assessed. To date, 160 scans have been completed.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL001159-01
Application #
6227871
Study Section
Special Emphasis Panel (CCMD)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Morse, Caryn G; Kovacs, Joseph A (2006) Metabolic and skeletal complications of HIV infection: the price of success. JAMA 296:844-54
Miller, Kirk D; Masur, Henry; Jones, Elizabeth C et al. (2002) High prevalence of osteonecrosis of the femoral head in HIV-infected adults. Ann Intern Med 137:17-25
Miller, K D; Spooner, K; Herpin, B R et al. (2001) Immunotherapy of HIV-infected patients with intermittent interleukin-2: effects of cycle frequency and cycle duration on degree of CD4(+) T-lymphocyte expansion. Clin Immunol 99:30-42