Assessment of occupational exposures is a crucial factor in evaluating dose-response relationships and most studies conducted by the Branch have an extensive exposure assessment component. Major assessment efforts in cohort studies have involved exposures to asbestos, organic solvents, pesticides, benzene, xylene, toluene, and diesel fumes. In the case-control design, jobs have been evaluated for a wide variety of exposures, including chlorinated hydrocarbons and other solvents, asbestos, formaldehyde, electromagnetic fields, physical activity, nitrosamines, polycyclic aromatic hydrocarbons, wood dust, diesel exhaust and pesticides. These exposures have been evaluated in studies of cancer of the peritoneum, breast, kidney, stomach, nasopharynx, esophagus, pancreas, brain, bladder, and lymphatic and hematopoietic system and for studies of parental occupation and childhood cancers. Methodologic studies are also conducted to improve exposure assessment techniques and to understand exposure patterns. A study is being initiated evaluating assessments made from detailed occupational questionnaires with air measurements. Comparison of jobs identified on death certificates is being made with work history records. Investigations were made on the reliability of industrial hygienists assessing exposures using written materials describing formaldehyde exposures and viewing a videotape of pesticide applications. In addition, a report describing how exposures to pesticides are being assessed in a large cohort study of pesticide appicators is being prepared. Two computer programs to assist in exposure assessment for cohort and for case-control studies are being developed. Two reviews of pesticide information available in the public arena provide guidance on how to assess exposures to migrant workers. A report describing the exposure assessment procedures in the Chinese benzene study was developed.

National Institute of Health (NIH)
Division of Cancer Epidemiology And Genetics (NCI)
Intramural Research (Z01)
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Cancer Epidemiology and Genetics
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Friesen, Melissa C; Bassig, Bryan A; Vermeulen, Roel et al. (2017) Evaluating Exposure-Response Associations for Non-Hodgkin Lymphoma with Varying Methods of Assigning Cumulative Benzene Exposure in the Shanghai Women's Health Study. Ann Work Expo Health 61:56-66
Locke, Sarah J; Deziel, Nicole C; Koh, Dong-Hee et al. (2017) Evaluating predictors of lead exposure for activities disturbing materials painted with or containing lead using historic published data from U.S. workplaces. Am J Ind Med 60:189-197
Friesen, Melissa C; Shortreed, Susan M; Wheeler, David C et al. (2015) Using hierarchical cluster models to systematically identify groups of jobs with similar occupational questionnaire response patterns to assist rule-based expert exposure assessment in population-based studies. Ann Occup Hyg 59:455-66
Friesen, Melissa C; Locke, Sarah J; Chen, Yu-Cheng et al. (2015) Historical occupational trichloroethylene air concentrations based on inspection measurements from shanghai, china. Ann Occup Hyg 59:62-78
Park, D U; Friesen, M C; Roh, H S et al. (2015) Estimating retrospective exposure of household humidifier disinfectants. Indoor Air 25:631-40
DellaValle, Curt T; Purdue, Mark P; Ward, Mary H et al. (2015) Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure. Ann Occup Hyg 59:609-15
Koh, Dong-Hee; Locke, Sarah J; Chen, Yu-Cheng et al. (2015) Lead exposure in US worksites: A literature review and development of an occupational lead exposure database from the published literature. Am J Ind Med 58:605-16
Wheeler, David C; Archer, Kellie J; Burstyn, Igor et al. (2015) Comparison of ordinal and nominal classification trees to predict ordinal expert-based occupational exposure estimates in a case-control study. Ann Occup Hyg 59:324-35
Friesen, Melissa C; Locke, Sarah J; Tornow, Carina et al. (2014) Systematically extracting metal- and solvent-related occupational information from free-text responses to lifetime occupational history questionnaires. Ann Occup Hyg 58:612-24
Koh, Dong-Hee; Nam, Jun-Mo; Graubard, Barry I et al. (2014) Evaluating temporal trends from occupational lead exposure data reported in the published literature using meta-regression. Ann Occup Hyg 58:1111-25

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