To help identify the presence of genetic contribution to the on set of lung cancer, we are examining chromosomal and gene specific changes in lung tumors from early and late age of onset lung cancer patients. Thus far, our study has showed that there is a distinct gene mutation spectrum between tumors having high chromosomal loss and those with lower levels of loss. We are expanding our current analyses to include whole genome analysis using CGH and gene expression analyses to determine the change between genetic alteration and gene expression profiles.
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| Landi, Maria Teresa; Dracheva, Tatiana; Rotunno, Melissa et al. (2008) Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival. PLoS ONE 3:e1651 |
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| Hong, Kyeong-Man; Yang, Sei-Hoon; Chowdhuri, Sinchita Roy et al. (2007) Inactivation of LLC1 gene in nonsmall cell lung cancer. Int J Cancer 120:2353-8 |
| Dracheva, Tatiana; Philip, Reena; Xiao, Wenming et al. (2007) Distinguishing lung tumours from normal lung based on a small set of genes. Lung Cancer 55:157-64 |
| Jin, Xiongjie; Zhang, Jianjun; Gao, Yanning et al. (2007) Relationship between mitochondrial DNA mutations and clinical characteristics in human lung cancer. Mitochondrion 7:347-53 |
| Yang, Sei Hoon; Mechanic, Leah E; Yang, Ping et al. (2005) Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. Clin Cancer Res 11:2106-10 |
| Hong, Kyeong-Man; Yang, Sei-Hoon; Guo, Mingzhou et al. (2005) Semiautomatic detection of DNA methylation at CpG islands. Biotechniques 38:354, 356, 358 |
| Dracheva, Tatiana; Jen, Jin (2003) Profiling lung adenocarcinoma: insights from genes and more genes. Cancer Biol Ther 2:299-300 |
