The objective of this project is to investigate local and systemic control of bone development by extracellular matrix components. Projects currently under study are: 1) purification of bone inductive proteins from human and bovine bone; 2) specificity of osteogenin action and its modulation by other growth factors; 3) transforming growth factors and bone differentiation; 4) role of collagenous substratum in bone induction; 5) influence of aluminum on mineralization during matrix-induced bone development, and 6) influence of demineralized dentin matrix on transformation of muscle into cartilage.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000204-10
Application #
3963701
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code