Acute renal failure has a high morbidity and mortality. We are working on the mechanism of action of three drugs(a-MSH and IL-10 and IL-13)that protect against renal injury in an animal model called ischemia-reperusion injury. We are also testing these agents in other forms of renal injury. Because this animal model does not reproduce many features of human acute renal failure, we are trying to find a better animal model. We have not suceeded yet.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Intramural Research (Z01)
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U.S. National Inst Diabetes/Digst/Kidney
United States
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Doi, Kent; Leelahavanichkul, Asada; Hu, Xuzhen et al. (2008) Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int 74:1017-25
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