Limited proteolysis of rat brain tubulin yields two types of products, those derived from carboxy terminal cleavage of both subunits and those derived from a single internal cut of each subunit. These changes have major effects on polymerization of tubulin: carboxy terminal cleavage promotes polymerization whereas internal cleavage hinders assembly. The carboxy terminal-cleaved tubulin promotes the assembly of uncleaved tubulin and tissues may use this mechanism to facilitate polymerization under unfavorable conditions.

Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
1986
Total Cost
Indirect Cost
Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
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