Metabolic Studies of Mouse Models of Obesity and Diabetes

Gavrilova, Oksana

Abstract

The following project have been supported by Mouse Metabolism Core Laboratory in FY 2008:? ? 1. 1 Z01 DK056020 GDDB? Regulation of metabolism by myostatin.? Principal Investigator: Alexandra McPherron (GDDB, NIDDK)? ? 2. 1 Z01 DK056021 GDDB? Role of GDF11 in the developing and adult pancreas ? Principal Investigator: Alexandra McPherron (GDDB, NIDDK)? ? 3. 1 Z01 DK013038 LBM? Regulation of rodent energy metabolism, body weight and composition? Principal Investigator: Kevin Hall (LBM, NIDDK).? ? 4. 1 Z01 DK013035 LBM ? Adipocyte development and insulin resistance? Principal Investigator: Vipul Periwal (LBM, NIDDK)? ? 5. 1 Z01 DK011007 CEB? Study of factors that induce differentiation of pancreatic precursor cells ? Principal Investigator: Marvin Gershengorn (CEB, NIDDK)? ? 6. 1 Z01 DK047044 CEB? High throughput screening for ligands for seven transmembrane-spanning receptors. ? Principal Investigator: Marvin Gershengorn (CEB, NIDDK)? ? 7. 1 Z01 DK055105 DB ? Cell cycle regulators in pancreatic development and disease? Principal Investigator: Sushil Rane (DB, NIDDK)? ? 8. 1 Z01 DK055106 DB ? Transforming growth factor - beta superfamily signaling in diabetes and obesity? Principal Investigator: Sushil Rane (DB, NIDDK)? ? 9. 1 Z01 DK055107 DB ? Cell Cycle Regulators in Diabetes and Obesity? Principal Investigator: Sushil Rane (DB, NIDDK)? ? 10. 1 Z01 DK075003 CEB ? Novel Regulators of PPARgamma? Principal Investigator: Kai Ge (CEB, NIDDK)? ? 11. 1 Z01 DK047055 CEB? Epigenetics and transcriptional regulation by PPARs.? Principal Investigator: Kai Ge (CEB, NIDDK)? ? 12. 1 Z01 DK056001 GDDB ? Brca1 in development and tumorigenesis. ? Principal Investigator - Chuxia Deng (GDDB, NIDDK)? ? 13. 1 Z01 DK031131 LBC? Role of muscarinic acetylcholine receptors in glucose and energy homeostasis? Principal Investigator: Jurgen Wess (LBC, NIDDK)? ? 14. 1 Z01 DK043313 MDB? Role of the Gnas Gene in Metabolic Regulation? Principal Investigator: Lee S. Weinstein (MDB, NIDDK)? ? 15. 1 Z01 DK043315 MDB? Role of Gs-alpha in central regulation of energy and glucose metabolism? Principal Investigator: Lee S. Weinstein (MDB, NIDDK)? ? 16. 1 Z01 DK043316 MDB? Role of Gs-alpha in regulation of adipose tissue growth and function? Principal Investigator: Lee S. Weinstein (MDB, NIDDK)? ? 17. 1 Z01 DK043317 MDB? Role of Gs-alpha in regulation of skeletal muscle metabolism? Principal Investigator: Lee S. Weinstein (MDB, NIDDK)? ? 18. 1 Z01 DK043318 MDB? Role of Gs-alpha in beta cell growth and function? Principal Investigator: Lee S. Weinstein (MDB, NIDDK)? ? 19. 1 Z01 DK055118 DB? Regulation of glucose transport in adipose cells? Principal Investigator: Samuel W Cushman (EDMN, NIDDK)? ? 20. 1 Z01 DK025102 MMB? Erythropoietin receptor and glucose metabolism? Principal Investigator: Constance T Noguchi (MCB, NIDDK)? ? 22. 1 Z01 DK069071 PECR? Structural analysis of candidate genes for type 2 diabetes and obesity? Principal Investigator: Leslie J Baier (PECR, NIDDK)? ? 23. 1 Z01 DK075004 DB? Identification of novel molecules and pathways that modulate adipogenesis? Principal Investigator: Elisabetta Mueller (GDDB, NIDDK)? ? 24. 1 Z01 DK061005 LGP? Genetic approaches to study cytokine control of metabolism? Principal Investigator: Lothar Hennighausen (LGP, NIDDK)? ? 25. 1 Z01 DK061000 LGP? Genetic Approaches To Understanding Organ Development And Function? Principal Investigator: Lothar Hennighausen (LGP, NIDDK)? ? 26. 1 Z01 DK057804 LMCB ? Adeno-associated virus-based gene delivery systems? Principal Investigator: Roland A Owens (LMCB, NIDDK)? ? 27. 1 Z01 DK015505 LCDB? Regulation of neutral lipid metabolism in adipocytes and other cells.? Principal Investigator: Constantine Londos (LCDB, NIDDK)? ? 28. 1 Z01 DK015615 LCDB? Neutral lipid droplets, associated PAT proteins, insulin insulin resistance? Principal Investigator: Constantine Londos (LCDB, NIDDK)? ? 29. Z01 DK056005 GDDB? Physiological roles of Ewings Sarcoma gene product EWS? Principal Investigator: Sean Lee (GDDB, NIDDK)? ? 30. 1 Z01 BC 008752 LMB? Thyroid hormone receptors in health and disease? Principal Investigator: Sheue-Yann Chen (LMB, NCI)? ? 31. 1 Z01 DC-000060 OB? Molecular analysis of human hereditary deafness? Principal Investigator: Andrew J. Griffith (MBG, NIDCD) ? ? 32.1 Z01 HL005012 CD? Reactive oxygen species, stem cells and aging? Principal Investigator: Toren Finkel (TMB, NHLBI) ? ? 33. 1 Z01 HD001602-23 CBMB? Regulation of intracellular iron metabolism? Principal Investigator: Tracey A. Rouault (HIM, NICHD)

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Intramural Research (Z01)
• Project #: 1Z01DK070002-04
• Application #: 7734320
• Support Year: 4
• Fiscal Year: 2008
• Total Cost: $301,652

Institution

• Name: National Institute of Diabetes and Digestive and Kidney Diseases
• Country: United States

Publications

Gautam, Dinesh; Jeon, Jongrye; Starost, Matthew F et al. (2009) Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A 106:6398-403

Pechhold, Klaus; Zhu, Xiaolong; Harrison, Victor S et al. (2009) Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes. Diabetes 58:1175-84

Guo, Juen; Jou, William; Gavrilova, Oksana et al. (2009) Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets. PLoS One 4:e5370

Guo, Tingqing; Jou, William; Chanturiya, Tatyana et al. (2009) Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One 4:e4937

Craig, Anthony T; Gavrilova, Oksana; Dwyer, Nancy K et al. (2009) Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors. Virol J 6:61

Jo, Junghyo; Gavrilova, Oksana; Pack, Stephanie et al. (2009) Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth. PLoS Comput Biol 5:e1000324

Lee, Ji-Yeon; Gavrilova, Oksana; Davani, Behrous et al. (2007) The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging. Biochim Biophys Acta 1773:1455-61

Cui, Yongzhi; Hosui, Atsushi; Sun, Rui et al. (2007) Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology 46:504-13

Cheung, Kevin J; Tzameli, Iphigenia; Pissios, Pavlos et al. (2007) Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab 5:115-28

Xie, Tao; Plagge, Antonius; Gavrilova, Oksana et al. (2006) The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice. J Biol Chem 281:18989-99