Abstract

Aims: To conduct a case-control study of PD nested in the Agricultural Health Study cohort, in order to determine whether increased risk of PD is associated with: pesticide exposure metal exposure exposure to Nocardia asteroides, a soil microorganism lifestyle factors including diet, cigarette smoking, and alcohol and caffeine use polymorphisms in genes involved in xenobiotic metabolism, or gene-environment interactions Accomplishments: The study will be a case-control study nested within the Agricultural Health Study, a large cohort study of 82,000 licensed pesticide applicators and their spouses. It will include ~160 cases and ~480 controls. This study is the first to investigate the relationship of pesticide exposure to PD prospectively, combining direct exposure measurements with detailed life histories of pesticide use. The study will have great power to address this issue, since virtually all cohort members are exposed to pesticides, although there is considerable variability within the cohort in exposure to specific chemicals. We have developed protocols and instruments for use in the field study, and expect to begin recruiting subjects in September, 2001.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Intramural Research (Z01)
Project #
1Z01ES044007-01
Application #
6535036
Study Section
Epidemiology and Biometry Training Committee (EB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst of Environ Hlth Scis
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Furlong, Melissa; Tanner, Caroline M; Goldman, Samuel M et al. (2015) Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease. Environ Int 75:144-50
Goldman, Samuel M; Kamel, Freya; Ross, G Webster et al. (2014) Peptidoglycan recognition protein genes and risk of Parkinson's disease. Mov Disord 29:1171-80
Kamel, Freya; Goldman, Samuel M; Umbach, David M et al. (2014) Dietary fat intake, pesticide use, and Parkinson's disease. Parkinsonism Relat Disord 20:82-7
Bronstein, Jeff; Carvey, Paul; Chen, Honglei et al. (2009) Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007. Environ Health Perspect 117:117-21
Kamel, F; Tanner, Cm; Umbach, Dm et al. (2007) Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. Am J Epidemiol 165:364-74
Beseler, Cheryl; Stallones, Lorann; Hoppin, Jane A et al. (2006) Depression and pesticide exposures in female spouses of licensed pesticide applicators in the agricultural health study cohort. J Occup Environ Med 48:1005-13
Kamel, Freya; Engel, Lawrence S; Gladen, Beth C et al. (2005) Neurologic symptoms in licensed private pesticide applicators in the agricultural health study. Environ Health Perspect 113:877-82
Blair, A; Sandler, D; Thomas, K et al. (2005) Disease and injury among participants in the Agricultural Health Study. J Agric Saf Health 11:141-50
Blair, Aaron; Sandler, Dale P; Tarone, Robert et al. (2005) Mortality among participants in the agricultural health study. Ann Epidemiol 15:279-85
Kamel, F; Umbach, D M; Hu, H et al. (2005) Lead exposure as a risk factor for amyotrophic lateral sclerosis. Neurodegener Dis 2:195-201

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