Abstract

Work conducted and/or published during 2008 has addressed several general areas: 1) in utero exposure to tobacco smoke and age at menarche 2) maternal serum concentrations of various inflammatory mediators and subsequent pregnancy outcome 3) risk factors for preeclampsia 4) stability of vitamin D in long-term storage. ? ? Papers published in topic 1 indicated girls exposed in utero to tobacco smoke experienced slightly later age at menarche than unexposed girls, in contrast to previous findings. ? ? Results from topic 2 indicated that elevated levels of the chemokine ENA-78 preceded the occurrence of miscarriage, but that levels of IL-8, MIP-1945;, MIP-1946;, MCP-1 and RANTES were not associated with this outcome. In addition, among cytokines, thrombopoietin was associated with miscarriage.? ? Results from topic 3 demonstrated that placental weight was an important correlate of small fetal growth. Other results indicated that obesity eliminated the inverse association between smoking and preeclampsia but did not alter the positive association between smoking and reduced fetal growth.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Intramural Research (Z01)
Project #
1Z01HD000383-18
Application #
7734689
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
18
Fiscal Year
2008
Total Cost
$164,671
Indirect Cost

  Institution

Name
Eunice Kennedy Shriver National Institute of Child Health & Human Development
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Trabert, Britton; Longnecker, Matthew P; Graubard, Barry I et al. (2011) Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus. Cancer Causes Control 22:689-95
Klebanoff, Mark A; Zhang, Jun; Zhang, Cuilin et al. (2009) Maternal serum theobromine and the development of preeclampsia. Epidemiology 20:727-32
Klebanoff, Mark A (2009) The Collaborative Perinatal Project: a 50-year retrospective. Paediatr Perinat Epidemiol 23:2-8
Ness, Roberta B; Zhang, Jun; Bass, Debra et al. (2008) Interactions between smoking and weight in pregnancies complicated by preeclampsia and small-for-gestational-age birth. Am J Epidemiol 168:427-33
Ness, Roberta B; Bass, Debra; Hill, Lyndon et al. (2007) Diagnostic test characteristics of placental weight in the prediction of small-for-gestational-age neonates. J Reprod Med 52:793-800
Johnson, Kimberly J; Spector, Logan G; Klebanoff, Mark A et al. (2007) Childhood cancer and birthmarks in the Collaborative Perinatal Project. Pediatrics 119:e1088-93
Pierik, Frank H; Klebanoff, Mark A; Brock, John W et al. (2007) Maternal pregnancy serum level of heptachlor epoxide, hexachlorobenzene, and beta-hexachlorocyclohexane and risk of cryptorchidism in offspring. Environ Res 105:364-9
Hemachandra, Anusha H; Howards, Penelope P; Furth, Susan L et al. (2007) Birth weight, postnatal growth, and risk for high blood pressure at 7 years of age: results from the Collaborative Perinatal Project. Pediatrics 119:e1264-70
Zhang, Yawei; Graubard, Barry I; Longnecker, Matthew P et al. (2007) Maternal hormone levels and perinatal characteristics: implications for testicular cancer. Ann Epidemiol 17:85-92
Bodnar, Lisa M; Catov, Janet M; Klebanoff, Mark A et al. (2007) Prepregnancy body mass index and the occurrence of severe hypertensive disorders of pregnancy. Epidemiology 18:234-9

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