Bacterial vaginosis is a syndrome in which the normal Lactobacillus-predominant vaginal flora is replaced with mixed anaerobic-predominant organisms. It is present in 10 to 25% of women in the general population, and is the most common vaginal infection. It has been associated with a number of adverse sequelae in reproductive health including acquisition of HIV, pelvic inflammatory disease, cervical dysplasia, and complications of gynecological procedures. During pregnancy it has been associated with an increased risk of preterm birth and postpartum maternal infection. However, the vaginal microbial flora remains poorly understood. Information on variation in microbial flora and its association with BV from a longitudinal study is unavailable. This prospective observational study aims to advance our knowledge of the natural history and abnormal alteration in vaginal microbial flora, and to identify risk factors that are associated with these changes. A total of 3600 healthy, non-pregnant women of reproductive age have been enrolled and are being followed in Birmingham, Alabama for one year (baseline visit plus once every three months afterwards, totaling five visits). Detailed information on sociodemographic status, medical history, hygiene practice, sexual behavior and psychosocial stress are collected through in-person interviews. Routine gynecological and dental examinations will be carried out during the study visits. Samples of vaginal secretion and blood are collected. Laboratory tests to quantify vaginal microbial flora and to identify infection of bacterial vaginosis as well as common sexually transmitted diseases are conducted. Sub-studies evaluate the day-to-day change in vaginal flora, and the effect of cessation of douching.

Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost
Name
U.S. National Inst/Child Hlth/Human Dev
Department
Type
DUNS #
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Country
United States
Zip Code
Klebanoff, Mark A; Turner, Abigail Norris (2014) Bacterial vaginosis and season, a proxy for vitamin D status. Sex Transm Dis 41:295-9
Klebanoff, Mark A; Andrews, William W; Zhang, Jun et al. (2010) Race of male sex partners and occurrence of bacterial vaginosis. Sex Transm Dis 37:184-90
Scifres, Christina M; Iams, Jay D; Klebanoff, Mark et al. (2009) Metaanalysis vs large clinical trials: which should guide our management? Am J Obstet Gynecol 200:484.e1-5
Wu, Mi-Xia; Yu, Kai F; Liu, Aiyi (2009) Exact inference on contrasts in means of intraclass correlation models with missing responses. J Multivar Anal 100:301-308
Brotman, Rebecca M; Klebanoff, Mark A; Nansel, Tonja R et al. (2008) A longitudinal study of vaginal douching and bacterial vaginosis--a marginal structural modeling analysis. Am J Epidemiol 168:188-96
Riggs, Margaret; Klebanoff, Mark; Nansel, Tonja et al. (2007) Longitudinal association between hormonal contraceptives and bacterial vaginosis in women of reproductive age. Sex Transm Dis 34:954-9
Klebanoff, Mark A (2007) Gestational age: not always what it seems. Obstet Gynecol 109:798-9
Brotman, Rebecca M; Erbelding, Emily J; Jamshidi, Roxanne M et al. (2007) Findings associated with recurrence of bacterial vaginosis among adolescents attending sexually transmitted diseases clinics. J Pediatr Adolesc Gynecol 20:225-31
Hendler, Israel; Andrews, William W; Carey, Christopher J et al. (2007) The relationship between resolution of asymptomatic bacterial vaginosis and spontaneous preterm birth in fetal fibronectin-positive women. Am J Obstet Gynecol 197:488.e1-5
Neggers, Yasmin H; Nansel, Tonja R; Andrews, William W et al. (2007) Dietary intake of selected nutrients affects bacterial vaginosis in women. J Nutr 137:2128-33

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