Systemic chemotherapy has become an integral part of primary treatment in patients with both advance and operable breast cancer. The morphological changes occurring in breast tissues have already been described, but the changes in molecular markers and the genetic variations that may occur in these tissues remain to be determine.We will study tissues obtained before and after treatment and evaluate prognostic markers as well as LOH at the p53, BRCA1 and BRCA2- locus.

Agency
National Institute of Health (NIH)
Institute
Division of Clinical Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01SC009392-07
Application #
6435308
Study Section
(LP)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Clinical Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
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Pak, Ho; Gourgiotis, Loukas; Chang, Wen-I et al. (2003) Role of metastasectomy in the management of thyroid carcinoma: the NIH experience. J Surg Oncol 82:10-8