The Baltimore Longitudinal Study of Aging (BLSA) was established in 1958 and is one the oldest prospective studies of aging in the USA and the world. The mission of the BLSA is to learn what happens to people as they get old and how to sort out changes due to aging and from those due to disease or other causes. Most of our analyses examine the trajectories of performance levels over time. However, we have suspected that there is important information in the inconsistencies in performance, and that greater within individual variability might be associated with subsequent cognitive impairment and dementia. In a case-control sample of Baltimore Longitudinal Study of Aging (mean SD age = 69.90 8.92) participants, we matched 135 clinically diagnosed demented participants with 135 non-demented participants based on age at initial testing and sex. Cognitive performance was examined using measures of memory, executive function, attention, language, and global mental status performance from initial assessment to 5 years before cognitive impairment (mean assessments = 3.03). Compared with unimpaired individuals, individuals diagnosed with dementia had greater variability on measures of attention, executive function, language, and semantic memory at least 5 years before the estimated onset of cognitive impairment, which may indicate maladaptive cognitive functioning. The dementia cases, however, had less variability on visual memory than the unimpaired group, which may suggest that these cases had more difficulty learning. These results suggest that performance variability indexed over annual or biennial visits may be useful in identifying early signs of subsequent cognitive impairment.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000185-23
Application #
8552327
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
23
Fiscal Year
2012
Total Cost
$499,913
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Fabbri, Elisa; An, Yang; Zoli, Marco et al. (2016) Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia. J Am Geriatr Soc 64:965-72
McCarrey, Anna C; An, Yang; Kitner-Triolo, Melissa H et al. (2016) Sex differences in cognitive trajectories in clinically normal older adults. Psychol Aging 31:166-75
Ibrahim-Verbaas, C A; Bressler, J; Debette, S et al. (2016) GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry 21:189-97
Gonzalez, Christopher E; Venkatraman, Vijay K; An, Yang et al. (2016) Peripheral sphingolipids are associated with variation in white matter microstructure in older adults. Neurobiol Aging 43:156-63
Levy, Becca R; Ferrucci, Luigi; Zonderman, Alan B et al. (2016) A culture-brain link: Negative age stereotypes predict Alzheimer's disease biomarkers. Psychol Aging 31:82-8
Beason-Held, Lori L; Hohman, Timothy J; Venkatraman, Vijay et al. (2016) Brain network changes and memory decline in aging. Brain Imaging Behav :
Korthauer, Laura E; Nowak, Nicole T; Moffat, Scott D et al. (2016) Correlates of virtual navigation performance in older adults. Neurobiol Aging 39:118-27
Mielke, Michelle M; Bandaru, Veera Venkata Ratnam; Han, Dingfen et al. (2015) Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell 14:1014-23
Tian, Qu; Resnick, Susan M; Ferrucci, Luigi et al. (2015) Intra-individual lap time variation of the 400-m walk, an early mobility indicator of executive function decline in high-functioning older adults? Age (Dordr) 37:115
Bigelow, Robin T; Semenov, Yevgeniy R; Trevino, Carolina et al. (2015) Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc 63:1837-44

Showing the most recent 10 out of 40 publications