Cognitive impairment places a severe burden upon both the sufferers and their carers. While approximately 5-10% of patients displaying cognitive impairment possess a genetic predisposition, such as a Flemish or Swedish mutation in the amyloid pre-cursor protein, the majority of patients do not possess such an obvious cause of their malady. The causes of age-dependent cognitive decline in the general population are likely to extremely diverse and therefore multifactorial. However there is one phenomenon that is generally expressed in the population, cognitive performance in tasks, that appears to be positively correlated to a prophylactic action against age-dependent neurodegeneration. This underlies the anecdotal adage of the use it or lose it phenomenon. Hence in this study we are attempting to understand not only the natural basis for cognitive capacity but also hopefully elucidate signaling mechanisms that are linked to this capacity that possess an intrinsic neuroprotective action. We are already nearing the completion of the first phase of this study in which we have used a large genetically identical murine pool of both male and female animals. We are in the process of generating a semi-quantitative relationship between protein expression in the cortex and hippocampus of these animals and their maze solving capacity. We feel that the data derived from this study will illuminate the field of cognition and provide a novel insight into the molecular basis of individual intellectual variation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000319-05
Application #
8552366
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2012
Total Cost
$243,878
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Stranahan, Alexis M; Martin, Bronwen; Maudsley, Stuart (2012) Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease. Curr Alzheimer Res 9:86-92
Maudsley, Stuart; Chadwick, Wayne (2012) Progressive and unconventional pharmacotherapeutic approaches to Alzheimer's disease therapy. Curr Alzheimer Res 9:1-4
Shin, Yu-Kyong; Cong, Wei-na; Cai, Huan et al. (2012) Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity. J Gerontol A Biol Sci Med Sci 67:336-44
Hallböök, Tove; Ji, Sunggoan; Maudsley, Stuart et al. (2012) The effects of the ketogenic diet on behavior and cognition. Epilepsy Res 100:304-9
Jiang, Mali; Wang, Jiawei; Fu, Jinrong et al. (2012) Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med 18:153-8
Jasien, Joan; Daimon, Caitlin M; Maudsley, Stuart et al. (2012) Aging and bone health in individuals with developmental disabilities. Int J Endocrinol 2012:469235
Maudsley, Stuart (2012) G protein-coupled receptor biased agonism: development towards future selective therapeutics. Mini Rev Med Chem 12:803
Cai, Huan; Cong, Wei-na; Ji, Sunggoan et al. (2012) Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders. Curr Alzheimer Res 9:5-17
Schwartz, Catherine M; Tavakoli, Tahereh; Jamias, Charmaine et al. (2012) Stromal factors SDF1*, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. J Neurosci Res 90:1367-81
Abdelmohsen, Kotb; Srikantan, Subramanya; Tominaga, Kumiko et al. (2012) Growth inhibition by miR-519 via multiple p21-inducing pathways. Mol Cell Biol 32:2530-48

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