This research is in progress. The hippocampus is crucial for memory formation. New neurons are added throughout life to the hippocampal dentate gyrus (DG), a brain area considered important for differential storage of similar experiences and contexts. To better understand the functional contribution of adult neurogenesis to pattern separation processes, we used a novel synapse specific trans-neuronal tracing approach to identify the (sub) cortical inputs to new dentate granule cells (GCs). It was observed that newly born neurons receive sequential innervation from structures important for memory function. Initially,septal-hippocampal cells provide input to new neurons, including transient innervation from mature GCs as well as direct feedback from area CA3 pyramidal neurons. After about 1 month perirhinal and lateral entorhinal cortex, brain areas deemed relevant to integration of novel sensory and environmental information, become substantial input to new GCs. The proposed functional relevance of new neurons, can now be examined within the context of their unique neural circuitry.

National Institute of Health (NIH)
National Institute on Aging (NIA)
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Vivar, Carmen; Peterson, Benjamin D; van Praag, Henriette (2016) Running rewires the neuronal network of adult-born dentate granule cells. Neuroimage 131:29-41
Moon, Hyo Youl; Becke, Andreas; Berron, David et al. (2016) Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Cell Metab 24:332-40
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Duzel, Emrah; van Praag, Henriette; Sendtner, Michael (2016) Can physical exercise in old age improve memory and hippocampal function? Brain 139:662-73
Guerrieri, Davide; van Praag, Henriette (2015) Exercise-mimetic AICAR transiently benefits brain function. Oncotarget 6:18293-313
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van Praag, Henriette; Fleshner, Monika; Schwartz, Michael W et al. (2014) Exercise, energy intake, glucose homeostasis, and the brain. J Neurosci 34:15139-49
Moon, Hyo Youl; van Praag, Henriette (2014) Muscle over mind. Cell Metab 20:560-2
Zhang, Zhi; Praag, Henriette van (2014) Maternal immune activation differentially impacts mature and adult-born hippocampal neurons in male mice. Brain Behav Immun :
Kobilo, Tali; Guerrieri, Davide; Zhang, Yongqing et al. (2014) AMPK agonist AICAR improves cognition and motor coordination in young and aged mice. Learn Mem 21:119-26

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