Abstract

Funding for a competitive renewal of the Program Project Grant that supports this research (AG16765, Dr. John H. Morrison, PD) was successfully secured during the current reporting period. Other project activities focused predominantly on the continuation and completion of ongoing long-term investigations examining the cognitive effects of several hormone treatment regimens in aged, ovariectormized rhesus monkeys. Those experiments, involving over 2 years of extensive neuropsychological assessment in each subject, are nearing completion. Continuing effort has also been directed at documenting the morphological effects of estrogen deficiency and treatment, and providing a window on the functional significance of observed effects, all results are evaluated in relation to the cognitive influence of hormone manipulation assessed in the same subjects. As detailed in a number of primary reports and reviews published during the current reporting period, the emerging results are consistent with the view that selective features of synaptic morphology and organization in the hippocampus and prefrontal cortex are sensitive to ovarian hormone regulation in the aged monkey brain, specifically in relation to the cognitive outcome of aging (e.g., Hara et al., 2011;Dumitriu et al., 2010;Wang et al., 2010).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000351-03
Application #
8335829
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2011
Total Cost
$101,306
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Crimins, Johanna L; Wang, Athena Ching-Jung; Yuk, Frank et al. (2017) Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause. Cereb Cortex 27:2022-2033
Snyder, Heather M; Asthana, Sanjay; Bain, Lisa et al. (2016) Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimers Dement 12:1186-1196
Hara, Yuko; Yuk, Frank; Puri, Rishi et al. (2016) Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys. J Neurosci 36:901-10
Naugle, Michelle M; Nguyen, Long T; Merceron, Tyler K et al. (2014) G-protein coupled estrogen receptor, estrogen receptor ?, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long-term estradiol treatment. J Exp Zool A Ecol Genet Physiol 321:399-414
Young, M E; Ohm, D T; Dumitriu, D et al. (2014) Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey. Neuroscience 274:33-43
Hara, Yuko; Yuk, Frank; Puri, Rishi et al. (2014) Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proc Natl Acad Sci U S A 111:486-91
Baxter, Mark G; Roberts, Mary T; Gee, Nancy A et al. (2013) Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys. Neurobiol Aging 34:1882-90
Hara, Yuko; Rapp, Peter R; Morrison, John H (2012) Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr) 34:1051-73
Ohm, Daniel T; Bloss, Erik B; Janssen, William G et al. (2012) Clinically relevant hormone treatments fail to induce spinogenesis in prefrontal cortex of aged female rhesus monkeys. J Neurosci 32:11700-5
Dumitriu, Dani; Rapp, Peter R; McEwen, Bruce S et al. (2010) Estrogen and the aging brain: an elixir for the weary cortical network. Ann N Y Acad Sci 1204:104-12

Showing the most recent 10 out of 12 publications