Caloric restriction (CR: reducing caloric intake 30-40 percent below ad libitum levels) has been repeatedly shown to extend lifespan, reduce the incidence and delay the onset of age-related disease, enhance stress protection, and attenuate functional decline in mammals. The NIA longitudinal study of CR and aging in rhesus monkeys is in its 25th year and recently published the survival findings. We reported findings of improved health;however, unlike findings from a similar study at the University of Wisconsin, the NIA CR monkeys did not have improved survival compared to the controls. Both studies are ongoing and we will continue to monitor the monkeys for age-related changes in many health parameters. Specifically we have ongoing studies assessing behavior including locomotor and motor performance. We have recently completed eye exams identifying traits consistent with macular degeneration. The monkeys have now had 5 exams in the last 7 years. We completed sample collection to identify markers consistent with intestinal cancers that might be similar between monkeys and humans. Additionally, fecal samples will be analyzed for the gut microbiota and compared to monkeys on the Wisconsin study and humans practicing CR.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000371-08
Application #
8736544
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2013
Total Cost
$570,354
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Mattison, Julie A; Vaughan, Kelli L (2016) An overview of nonhuman primates in aging research. Exp Gerontol :
Sitzmann, Brandon D; Brown, Donald I; Garyfallou, Vasilios T et al. (2014) Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta). Age (Dordr) 36:183-97
Urbanski, Henryk F; Mattison, Julie A; Roth, George S et al. (2013) Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies. Exp Gerontol 48:1136-9
Mercken, Evi M; Majounie, Elisa; Ding, Jinhui et al. (2013) Age-associated miRNA alterations in skeletal muscle from rhesus monkeys reversed by caloric restriction. Aging (Albany NY) 5:692-703
Mattison, Julie A; Roth, George S; Beasley, T Mark et al. (2012) Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489:318-21
Smith Jr, Daniel L; Mattison, Julie A; Desmond, Renee A et al. (2011) Telomere dynamics in rhesus monkeys: no apparent effect of caloric restriction. J Gerontol A Biol Sci Med Sci 66:1163-8
Stenholm, Sari; Metter, E Jeffrey; Roth, George S et al. (2011) Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore Longitudinal Study of Aging. Aging Clin Exp Res 23:153-8
Simmons, Heather A; Mattison, Julie A (2011) The incidence of spontaneous neoplasia in two populations of captive rhesus macaques (Macaca mulatta). Antioxid Redox Signal 14:221-7
Minor, Robin K; Smith Jr, Daniel L; Sossong, Alex M et al. (2010) Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol Appl Pharmacol 243:332-9
Gouras, Peter; Ivert, Lena; Neuringer, Martha et al. (2010) Topographic and age-related changes of the retinal epithelium and Bruch's membrane of rhesus monkeys. Graefes Arch Clin Exp Ophthalmol 248:973-84

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