Gene expression analysis by Illumina microarray yielded several lines of investigation. Several expression patterns were analyzed by quantitative RT-PCR, 62 of which were consistently upregulated in all three phenotypes of drug resistance. Pathway enrichment methods were utilized to further understand the possible signaling mechanisms common to these 62 genes. The databases employed were KEGG, GO and Reactome. The pathways most strongly implicated were cell surface and cell movement, translation and oxidative stress as well as proteosome regulatio and steroid biosynthesis.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000396-06
Application #
8736559
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$216,977
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Li, Jianghong; Chigurupati, Srinivasulu; Agarwal, Rachana et al. (2009) Possible angiogenic roles for claudin-4 in ovarian cancer. Cancer Biol Ther 8:1806-14
Morin, Patrice J (2008) Learning about ovarian tumorigenesis by watching Cables. Cancer Biol Ther 7:189-90