Claudin 7 knockdown revealed gene expression patturns that implicated its role several pathways including cell cycle, proliferation and death as well as cell migration. Since these pathways are extremely relevant to cancer progression and metastsis, we investigated these further. After using various methods such as we concluded that claudin-7 provided contributed in increased invasion but interestingly decreased migration. It would be fascinating to further tease out the role of of claudin 7 in these two tightly regulated and entwined mechanisms

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000397-06
Application #
8736560
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$289,303
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Lal-Nag, Madhu; Morin, Patrice J (2009) The claudins. Genome Biol 10:235
D'Souza, Theresa; Sherman-Baust, Cheryl A; Poosala, Suresh et al. (2009) Age-related changes of claudin expression in mouse liver, kidney, and pancreas. J Gerontol A Biol Sci Med Sci 64:1146-53
Li, Jianghong; Sherman-Baust, Cheryl A; Tsai-Turton, Miyun et al. (2009) Claudin-containing exosomes in the peripheral circulation of women with ovarian cancer. BMC Cancer 9:244