Abstract

MR is an excellent modality for detailed metabolic investigations in human subject. We were interested in the link between muscle architecture and functional measures. Muscle architecture is probed by several MR methods related to diffusion, including anomalous diffusion measures and diffusion tensor imaging. Functional measures are those of the BLSA, and include force, muscle quality, and bioenergetic measures. We are finding a signal towards greater sarcomere fragmentation in the older populations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000924-09
Application #
9351982
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

AlGhatrif, Majd; Zane, Ariel; Oberdier, Matt et al. (2017) Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low-Normal Ankle-Brachial Index. J Am Heart Assoc 6:
Zane, Ariel C; Reiter, David A; Shardell, Michelle et al. (2017) Muscle strength mediates the relationship between mitochondrial energetics and walking performance. Aging Cell 16:461-468
Fabbri, Elisa; Chia, Chee W; Spencer, Richard G et al. (2017) Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging. Diabetes 66:170-176
Cameron, Donnie; Bouhrara, Mustapha; Reiter, David A et al. (2017) The effect of noise and lipid signals on determination of Gaussian and non-Gaussian diffusion parameters in skeletal muscle. NMR Biomed 30:
Reiter, David A; Magin, Richard L; Li, Weiguo et al. (2016) Anomalous T2 relaxation in normal and degraded cartilage. Magn Reson Med 76:953-62
Makrogiannis, S; Fishbein, K W; Moore, A Z et al. (2016) Image-Based Tissue Distribution Modeling for Skeletal Muscle Quality Characterization. IEEE Trans Biomed Eng 63:805-13
Bouhrara, Mustapha; Spencer, Richard G (2015) Incorporation of nonzero echo times in the SPGR and bSSFP signal models used in mcDESPOT. Magn Reson Med 74:1227-35
Celik, Hasan; Bouhrara, Mustapha; Reiter, David A et al. (2013) Stabilization of the inverse Laplace transform of multiexponential decay through introduction of a second dimension. J Magn Reson 236:134-9
Spencer, Richard G; Pleshko, Nancy (2013) How do statistical differences in matrix-sensitive magnetic resonance outcomes translate into clinical assignment rules? J Am Acad Orthop Surg 21:438-9
Irrechukwu, Onyi N; Reiter, David A; Lin, Ping-Chang et al. (2012) Characterization of engineered cartilage constructs using multiexponential T? relaxation analysis and support vector regression. Tissue Eng Part C Methods 18:433-43

Showing the most recent 10 out of 23 publications