This project uses the NHANES 1999-2004 data on body composition to examine the prevalence of sarcopenia in the U.S. population. We created a new definition of non-sarcopenic adults based on data from normal weight persons aged 20-39 in the U.S. population and used it to explored the prevalence of sarcopenia in persons aged 40 and older. We are particularly interested in the presence of sarcopenia in men and women over age 70. We will consider how the definitions of sarcopenia and myosteatosis are affected by race, ethnicity or weight. It is unclear if one definition of sarcopenia based on body composition alone can describe the association of body composition with disability for very thin and very heavy individuals. This project aims to assist the American Geriatrics Society in creation of a working definition of sarcopenia for geriatric practice.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG004050-04
Application #
8336010
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2011
Total Cost
$55,171
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Fragala, Maren S; Dam, Thuy-Tien L; Barber, Vanessa et al. (2015) Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health sarcopenia project. J Gerontol A Biol Sci Med Sci 70:202-9
McLean, Robert R; Shardell, Michelle D; Alley, Dawn E et al. (2014) Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci 69:576-83
Cawthon, Peggy M; Peters, Katherine W; Shardell, Michelle D et al. (2014) Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci 69:567-75
Dam, Thuy-Tien; Peters, Katherine W; Fragala, Maren et al. (2014) An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci 69:584-90
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